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Literature summary for 1.1.3.13 extracted from

  • Leonovich, O.; Kurales, Y.; Dutova, T.; Isakova, E.; Deryabina, Y.; Rabinovich, Y.
    The regulation of peroxisomal matrix enzymes (alcohol oxidase and catalase) formation by the product of the gene Mth1 in methylotrophic yeast Pichia methanolica (2009), Appl. Biochem. Microbiol., 45, 137-142.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
methanol induces enzyme expression at 3% Ogataea methanolica

Cloned(Commentary)

Cloned (Comment) Organism
AUG, MOD1, and AUG, MOD2 of Pichia methanolica are genes encoding AO, the AUG2 gene encodes one of the subunits of the alcohol oxodase and the catalase CTA1 of the organism. Genotyping of isozymes in different strains, overview Ogataea methanolica

Protein Variants

Protein Variants Comment Organism
additional information two mutant strains possess defects in genes MTH1 and MTH2, which result in the inability to assimilate methanol as a sole carbon source and increased activity of alcohol oxidase, AO. The mutant mth1 possesses a dominant formation of AO isoform with electrophoretic mobility which is typical for isogenic form 9, the product of the AUG2 gene, and a decreased level of peroxisomal catalase, phenotypes, overview Ogataea methanolica

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
Ogataea methanolica 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ethanol + O2 Ogataea methanolica
-
acetaldehyde + H2O2
-
?
additional information Ogataea methanolica correlation of activity of peroxisomal catalase and AO isogenic form 1 under different conditions reveal common regulatory elements for genes AUG2 and CTA1 ?
-
?

Organism

Organism UniProt Comment Textmining
Ogataea methanolica
-
9 isozymes, strains 616 and MH4-1032
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethanol + O2
-
Ogataea methanolica acetaldehyde + H2O2
-
?
additional information correlation of activity of peroxisomal catalase and AO isogenic form 1 under different conditions reveal common regulatory elements for genes AUG2 and CTA1 Ogataea methanolica ?
-
?

Subunits

Subunits Comment Organism
octamer
-
Ogataea methanolica

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Ogataea methanolica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Ogataea methanolica

General Information

General Information Comment Organism
physiological function the peroxisomal enzyme alcohol oxidase plays key role in methanol dissimilation in yeast Ogataea methanolica