BRENDA - Enzyme Database
show all sequences of 1.1.2.4

Kinetic activation of yeast mitochondrial d-lactate dehydrogenase by carboxylic acids

Mourier, A.; Vallortigara, J.; Yoboue, E.D.; Rigoulet, M.; Devin, A.; Biochim. Biophys. Acta 1777, 1283-1288 (2008)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
carboxylic acid
activates, stimulation is non-competitive, hyperbolic and its dimension is directly related to the number of carboxylic groups on the activator. Stimulation does not affect the yield of oxidative phosphorylation
Saccharomyces cerevisiae
D-lactate
stimulation with D-lactate as substrate, is insensitive to malate or pyruvate addition
Saccharomyces cerevisiae
L-malate
non-competitive activation
Saccharomyces cerevisiae
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Saccharomyces cerevisiae
5739
-
Organism
Organism
UniProt
Commentary
Textmining
Saccharomyces cerevisiae
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
culture condition:aerobically-grown cell
-
Saccharomyces cerevisiae
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
(R)-lactate + ferricyanide
-
685358
Saccharomyces cerevisiae
pyruvate + ferrocyanide
-
-
-
?
(R)-lactate + ferricytochrome c
-
685358
Saccharomyces cerevisiae
pyruvate + ferrocytochrome c
-
-
-
?
D-lactate + cytochrome c2ox
-
685358
Saccharomyces cerevisiae
pyruvate + cytochrome c2red
-
-
-
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
carboxylic acid
activates, stimulation is non-competitive, hyperbolic and its dimension is directly related to the number of carboxylic groups on the activator. Stimulation does not affect the yield of oxidative phosphorylation
Saccharomyces cerevisiae
D-lactate
stimulation with D-lactate as substrate, is insensitive to malate or pyruvate addition
Saccharomyces cerevisiae
L-malate
non-competitive activation
Saccharomyces cerevisiae
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Saccharomyces cerevisiae
5739
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
culture condition:aerobically-grown cell
-
Saccharomyces cerevisiae
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
(R)-lactate + ferricyanide
-
685358
Saccharomyces cerevisiae
pyruvate + ferrocyanide
-
-
-
?
(R)-lactate + ferricytochrome c
-
685358
Saccharomyces cerevisiae
pyruvate + ferrocytochrome c
-
-
-
?
D-lactate + cytochrome c2ox
-
685358
Saccharomyces cerevisiae
pyruvate + cytochrome c2red
-
-
-
?
Other publictions for EC
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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743861
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227-232
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2
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698932
Engqvist
Two D-2-hydroxy-acid dehydroge ...
Arabidopsis thaliana
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25026-25037
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706465
Pohanka
-
D-Lactate dehydrogenase (cytoc ...
Saccharomyces cerevisiae
Pol. J. Chem.
83
415-420
2009
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685358
Mourier
Kinetic activation of yeast mi ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
1777
1283-1288
2008
3
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703801
Pohanka
-
Amperometric biosensor for D-l ...
Saccharomyces cerevisiae
Food Technol. Biotechnol.
46
107-110
2008
-
1
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672749
Hao
Pseudomonas stutzeri as a nove ...
Pseudomonas stutzeri
Biotechnol. Lett.
29
105-110
2007
1
1
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1
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684629
Ma
Membrane-bound L- and D-lactat ...
Pseudomonas stutzeri
Appl. Microbiol. Biotechnol.
77
91-98
2007
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1
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672323
Atlante
Transport and metabolism of D- ...
Helianthus tuberosus
Biochim. Biophys. Acta
1708
13-22
2005
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655064
Horikiri
Electron acquisition system co ...
Rhodopseudomonas palustris
Biosci. Biotechnol. Biochem.
68
516-522
2004
-
-
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1
1
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2
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1
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1
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2
1
1
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1
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1
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1
1
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389633
Lodi
Regulation of the Saccharomyce ...
Saccharomyces cerevisiae
Mol. Gen. Genet.
262
623-632
1999
1
-
1
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1
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2
1
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2
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389632
Lodi
Transcriptional regulation of ...
Kluyveromyces lactis
Curr. Genet.
34
12-20
1998
-
-
1
-
1
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1
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3
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389631
Lodi
Carbon catabolite repression i ...
Kluyveromyces lactis
Mol. Gen. Genet.
244
622-629
1994
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1
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389630
Ogata
D-Lactate dehydrogenase of Des ...
Desulfovibrio vulgaris
J. Biochem.
89
1423-1431
1981
1
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5
1
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3
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389628
Olson
Purification and properties of ...
Megasphaera elsdenii
Biochemistry
18
4714-4723
1979
-
-
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1
1
1
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3
2
1
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1
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389629
Olson
Suicide inactivation of the fl ...
Megasphaera elsdenii
Biochemistry
18
4724-4731
1979
-
-
-
-
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2
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1
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1
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1
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3
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287801
Hatefi
-
Metal-containing flavoprotein ...
Saccharomyces cerevisiae
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
13
175-297
1976
-
-
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1
4
1
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1
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389626
Brockman
D-lactate dehydrogenase of Pep ...
Megasphaera elsdenii
Methods Enzymol.
41B
309-312
1975
-
-
-
-
-
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1
3
-
3
1
1
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3
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1
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389623
Gregolin
The lactic dehydrogenase of ye ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
67
201-218
1963
-
-
-
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1
4
4
1
1
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1
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1
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1
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3
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2
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3
3
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3
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1
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4
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1
1
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1
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1
1
3
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1
2
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3
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389625
Nygaard
-
Lactate dehydrogenases of yeas ...
Saccharomyces cerevisiae
The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
7
557-565
1963
-
-
-
-
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1
-
1
3
-
1
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1
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4
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4
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4
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1
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3
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1
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4
-
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389624
Nygaard
D(-)-lactic cytochrome c reduc ...
Saccharomyces cerevisiae
J. Biol. Chem.
236
920-925
1961
-
-
-
-
-
-
3
3
1
1
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1
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2
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1
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1
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5
-
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1
2
2
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3
2
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3
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3
2
3
1
1
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1
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5
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1
2
2
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