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Literature summary for 1.1.1.B40 extracted from

  • Guan, H.; Sun, K.; Yang, K.
    The ERK1/2 signaling pathway regulates 11beta-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through a transcriptional mechanism (2013), Biol. Reprod., 89, 92 .
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the JNK inhibitor SP600125 has no effect on 11beta-HSD2 enzyme activity Homo sapiens
U0126 the ERK1/2 inhibitor activates 11beta-HSD2 enzyme activity 3fold Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene HSD11B2, two-step real-time quantitative RT-PCR isozyme 11beta-HSD2 expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ the ERK1/2 inhibitor U0126 can block cadmium-induced inhibition of placental 11beta-HSD2. Cadmium does not alter activities of p38 MAPK, JNK, or PI3 kinase. Cadmium specifically activates the ERK1/2 signaling pathway in human trophoblast cells Homo sapiens
additional information the JNK inhibitor SP600125 has no effect on 11beta-HSD2 enzyme activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P80365
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-
trophoblast placental trophoblast cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
11beta-HSD2
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase type 2
-
Homo sapiens
Hsd11B2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of placental 11beta-HSD2 is regulated at both transcriptional and posttranscriptional levels. JNK inhibitor SP600125 has no effect on 11beta-HSD2 isozyme expression additional information
Homo sapiens p38 MAPK enhances placental 11beta-HSD2 expression by a posttranscriptional mechanism. ERK1/2 inhibitor U0126 induces the enzyme expression in trophoblasts. siRNA-mediated knockdown of ERK1/2 expression leads to a similar increase in levels of 11beta-HSD2 protein, as seen in cells treated with the ERK1/2 pharmacological inhibitor up

General Information

General Information Comment Organism
physiological function the enzyme plays a key role in fetal development. p38 MAPK is a positive regulator of placental 11beta-HSD2, p38 MAPK upregulates placental 11b-HSD2 by increasing the half-life of 11beta-HSD2 mRNA. Also ERK1/2 signaling is involved in regulation of placental 11beta-HSD2, ERK1/2 inhibitor U0126 induces the enzyme expression in trophoblasts. siRNA-mediated knockdown of ERK1/2 expression leads to a similar increase in levels of 11beta-HSD2 protein, as seen in cells treated with the ERK1/2 pharmacological inhibitor Homo sapiens