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Literature summary for 1.1.1.B40 extracted from

  • Xu, D.; Sheng, Y.; Zhou, Z.Y.; Liu, R.; Leng, Y.; Liu, J.K.
    Sesquiterpenes from cultures of the basidiomycete Clitocybe conglobata and their 11 beta-hydroxysteroid dehydrogenase inhibitory activity (2009), Chem. Pharm. Bull., 57, 433-435.
    View publication on PubMed
Search for more literature for 1.1.1.B40

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cell Mus musculus
overexpressed in HEK-293 cell Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
 Homo sapiens
(4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
 Mus musculus
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
 Homo sapiens
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
-
 Mus musculus
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
-
 Homo sapiens
(4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
-
 Mus musculus
glycyrrhizininc acid
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NAD+
-
 Mus musculus cortisone + NADH + H+
-
 ?
cortisol + NAD+
-
 Homo sapiens cortisone + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase 2
-
 Mus musculus
11beta-hydroxysteroid dehydrogenase 2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus
NAD+
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC50 = 0.177 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
 IC50 = 0.2 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
additional information
-
 IC50 = 0.22 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
 IC50 = 0.2505 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus (4aS,5R,8aR)-5,6-bis(hydroxymethyl)-1,1,4a-trimethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
 IC50 = 0.3303 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-ol
additional information
-
 IC50 = 0.5002 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus (4aS,5S,8aR)-5-(hydroxymethyl)-1,1,4a,6-tetramethyl-3,4,4a,5,8,8a-hexahydronaphthalen-2(1H)-one
0.00000071
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens glycyrrhizininc acid