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Literature summary for 1.1.1.B40 extracted from
- Structure-dependent inhibition of human and rat 11beta-hydroxysteroid dehydrogenase 2 activities by phthalates (2010), Chem. Biol. Interact., 183, 79-84.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| di-n-butyl phthalate | - |
Homo sapiens |  |
| di-n-butyl phthalate | - |
Rattus norvegicus | |
| di-n-octyl phthalate | - |
Homo sapiens | |
| di-n-octyl phthalate | - |
Rattus norvegicus | |
| di-n-pentyl phthalate | - |
Homo sapiens | |
| di-n-pentyl phthalate | - |
Rattus norvegicus | |
| dicyclohexyl phthalate | - |
Homo sapiens | |
| dicyclohexyl phthalate | - |
Rattus norvegicus | |
| diethyl phthalate | - |
Homo sapiens | |
| diethyl phthalate | - |
Rattus norvegicus | |
| dipropyl phthalate | - |
Homo sapiens | |
| dipropyl phthalate | - |
Rattus norvegicus | |
| mono (2-ethylhexyl) phthalate | competitive inhibitor of 11beta-HSD2, possibly via competing with the cofactor NAD+ | Homo sapiens | |
| mono (2-ethylhexyl) phthalate | competitive inhibitor of 11beta-HSD2, possibly via competing with the cofactor NAD+ | Rattus norvegicus | |
| additional information | not inhibited by dimethyl phthalate, butylbenzyl phthalate, di(2-ethylhexyl) phthalate, di-n-heptyl phthalate, diisononyl phthalate, and diisodecyl phthalate | Homo sapiens | |
| additional information | not inhibited by dimethyl phthalate, butylbenzyl phthalate, di(2-ethylhexyl) phthalate, di-n-heptyl phthalate, diisononyl phthalate, and diisodecyl phthalate | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| corticosterone + NAD+ | - |
Homo sapiens | 11-dehydrocorticosterone + NADH + H+ | - |
? | |
| corticosterone + NAD+ | - |
Rattus norvegicus | 11-dehydrocorticosterone + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-HSD2 | - |
Homo sapiens |
| 11beta-HSD2 | - |
Rattus norvegicus |
| 11beta-hydroxysteroid dehydrogenase 2 | - |
Homo sapiens |
| 11beta-hydroxysteroid dehydrogenase 2 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
| NAD+ | - |
Rattus norvegicus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.01369 | - |
- |
Rattus norvegicus | di-n-butyl phthalate | |
| 0.03264 | - |
- |
Rattus norvegicus | dicyclohexyl phthalate | |
| 0.08559 | - |
- |
Rattus norvegicus | dipropyl phthalate | |
| 0.1108 | - |
- |
Homo sapiens | mono (2-ethylhexyl) phthalate | |
| 0.1218 | - |
- |
Rattus norvegicus | mono (2-ethylhexyl) phthalate | |
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