Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | isozyme 11beta-HSD2 expression is highly reduced in proliferating cells | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | Rattus norvegicus | isozyme 11beta-HSD2 is involved in inactivation of glucocorticoids, forskolin is involved in regulation of isozyme 11beta-HSD2 via intracellular cAMP | cortisone + NADH | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
isozyme 11beta-HSD2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | isozyme 11beta-HSD2 expression is highly reduced in proliferating cells | Rattus norvegicus | - |
Schwann cell | mainly isozyme 11beta-HSD2, the concentration of isozyme 11beta-HSD1 is 10-100fold lower, expression analysis, isozyme 11beta-HSD2 shows strong expression and activity in quiescent cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+ | Rattus norvegicus | cortisone + NADH | - |
ir | |
cortisol + NAD+ | isozyme 11beta-HSD2 is involved in inactivation of glucocorticoids, forskolin is involved in regulation of isozyme 11beta-HSD2 via intracellular cAMP | Rattus norvegicus | cortisone + NADH | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD2 | - |
Rattus norvegicus |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus |