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Literature summary for 1.1.1.B20 extracted from

  • Otagiri, M.; Ui, S.; Takusagawa, Y.; Ohtsuki, T.; Kurisu, G.; Kusunoki, M.
    Structural basis for chiral substrate recognition by two 2,3-butanediol dehydrogenases (2010), FEBS Lett., 584, 219-223.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
N146F 11% of wild-type specific activity Corynebacterium glutamicum
Q140I trace activity below 0.1 U/mg Corynebacterium glutamicum
Q140I/N146F poor activity Corynebacterium glutamicum
Q140I/N146F/W190H trace activity below 0.1 U/mg with substrate meso-butanediol, 2.9 U/mg with substrate (2S,3S)-2,3-butanediol Corynebacterium glutamicum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2
-
meso-2,3-butanediol pH 8.0, 37°C Corynebacterium glutamicum

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1
-
mutant N146F, substrate (2S,3S)-2,3-butanediol, pH 8.0, 37°C Corynebacterium glutamicum
2.9
-
mutant Q140I/N146F/W190H, substrate (2S,3S)-2,3-butanediol, pH 8.0, 37°C Corynebacterium glutamicum
3.1
-
mutant Q140I/N146F, substrate (2,3S)-2,3-butanediol, pH 8.0, 37°C Corynebacterium glutamicum
4.5
-
mutant Q140I/N146F, substrate meso-2,3-butanediol, pH 8.0, 37°C Corynebacterium glutamicum
5.5
-
wild-type, substrate (2S,3S)-2,3-butanediol, pH 8.0, 37°C Corynebacterium glutamicum
19.4
-
mutant N146F, substrate meso-2,3-butanediol, pH 8.0, 37°C Corynebacterium glutamicum
177
-
wild-type, substrate meso-2,3-butanediol, pH 8.0, 37°C Corynebacterium glutamicum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S,3S)-2,3-butanediol + NAD+ (2S,3S)-2,3-butanediol is a poor substrate Corynebacterium glutamicum (3S)-acetoin + NADH
-
?
meso-2,3-butanediol + NAD+
-
Corynebacterium glutamicum acetoin + NADH
-
?

Synonyms

Synonyms Comment Organism
meso-BD
-
Corynebacterium glutamicum