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Literature summary for 1.1.1.90 extracted from
- Benzyl alcohol dehydrogenase and benzaldehyde dehydrogenase II from Acinetobacter calcoaceticus. Substrate specificities and inhibition studies (1988), Biochem. J., 255, 653-661.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Bromobenzaldehyde | 0.01 mM, 88% inhibition | Acinetobacter calcoaceticus |  |
| 2-Chlorobenzaldehyde | 0.01 mM, 95% inhibition | Acinetobacter calcoaceticus | |
| 2-Fluorobenzaldehyde | 0.1 mM, 100% inhibition | Acinetobacter calcoaceticus | |
| 3,4-dimethoxybenzaldehyde | 0.1 mM, 10% inhibition | Acinetobacter calcoaceticus | |
| 3-methylbenzaldehyde | 0.1 mM, 75% inhibition | Acinetobacter calcoaceticus | |
| 4-Isopropylbenzaldehyde | 0.01 mM, 87% inhibition | Acinetobacter calcoaceticus | |
| iodoacetamide | slight | Acinetobacter calcoaceticus | |
| iodoacetate | - |
Acinetobacter calcoaceticus | |
| N-ethylmaleimide | - |
Acinetobacter calcoaceticus | |
| p-chloromercuribenzoate | - |
Acinetobacter calcoaceticus | |
| pentafluorobenzaldehyde | 0.1 mM, 44% inhibition | Acinetobacter calcoaceticus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.018 | - |
perillyl alcohol | - |
Acinetobacter calcoaceticus | |
| 0.026 | - |
benzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 0.044 | - |
coniferyl alcohol | - |
Acinetobacter calcoaceticus | |
| 0.046 | - |
4-Hydroxybenzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 0.053 | - |
3,4-dimethoxybenzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 0.057 | - |
4-methoxybenzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 0.09 | - |
2-hydroxybenzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 0.093 | - |
cinnamyl alcohol | - |
Acinetobacter calcoaceticus | |
| 0.111 | - |
2-Methoxybenzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 0.111 | - |
4-Isopropylbenzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 0.111 | - |
thiophen-2-methanol | - |
Acinetobacter calcoaceticus | |
| 0.145 | - |
3-Methoxybenzyl alcohol | - |
Acinetobacter calcoaceticus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyl alcohol + NAD+ | Acinetobacter calcoaceticus | - |
benzaldehyde + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acinetobacter calcoaceticus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-hydroxybenzyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | 2-hydroxybenzaldehyde + NADH | - |
r | |
| 2-hydroxymethylthiophene + NAD+ | - |
Acinetobacter calcoaceticus | 2-formylthiophene + NADH | - |
r | |
| 2-methoxybenzyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | 2-methoxybenzaldehyde + NADH | - |
r | |
| 3,4-dimethoxybenzyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | 3,4-dimethoxybenzaldehyde + NADH | - |
r | |
| 3-methoxybenzyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | 3-methoxybenzaldehyde + NADH | - |
? | |
| 4-hydroxy-3-methoxybenzyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | 4-hydroxy-3-methoxybenzaldehyde + NADH | - |
r | |
| 4-hydroxybenzyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | 4-hydroxybenzaldehyde + NADH | - |
r | |
| 4-isopropylbenzyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | 4-isopropylbenzaldehyde + NADH | - |
r | |
| 4-methoxybenzyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | 4-methoxybenzaldehyde + NADH | - |
r | |
| benzyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | benzaldehyde + NADH | - |
? | |
| cinnamyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | cinnamic aldehyde + NADH | - |
r | |
| coniferyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | coniferyl aldehyde + NADH + H+ | - |
r | |
| furan-2-methanol + NAD+ | - |
Acinetobacter calcoaceticus | 2-formylfuran + NADH | - |
r | |
| additional information | alcohols that are not oxidized | Acinetobacter calcoaceticus | ? | - |
? | |
| perillyl alcohol + NAD+ | - |
Acinetobacter calcoaceticus | perillaldehyde + NADH | - |
r | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 80 | - |
4-Hydroxybenzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 83 | - |
perillyl alcohol | - |
Acinetobacter calcoaceticus | |
| 116 | - |
4-methoxybenzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 131 | - |
benzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 141 | - |
cinnamyl alcohol | - |
Acinetobacter calcoaceticus | |
| 144 | - |
4-Isopropylbenzyl alcohol | - |
Acinetobacter calcoaceticus | |
| 156 | - |
3-Methoxybenzyl alcohol | - |
Acinetobacter calcoaceticus | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Acinetobacter calcoaceticus | |
| NADH | - |
Acinetobacter calcoaceticus | |
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