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Literature summary for 1.1.1.85 extracted from

  • Pallo, A.; Olah, J.; Graczer, E.; Merli, A.; Zavodszky, P.; Weiss, M.S.; Vas, M.
    Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis (2014), FEBS J., 281, 5063-5076.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with Mn2+, (2R,3S)-3-isopropylmalate, and NADH, hanging drop vapor diffusion method, using 20% (w/v) PEG 6000, 0.1 M MOPS/KOH, pH 7.6, and 10% (v/v) ethanol Thermus thermophilus

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2R,3S)-3-isopropylmalate + NAD+ Thermus thermophilus
-
(2S)-2-isopropyl-3-oxosuccinate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2R,3S)-3-isopropylmalate + NAD+
-
Thermus thermophilus (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
-
r

Synonyms

Synonyms Comment Organism
IPMDH
-
Thermus thermophilus
isopropylmalate dehydrogenase
-
Thermus thermophilus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Thermus thermophilus