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Literature summary for 1.1.1.81 extracted from
- Tartaric acid metabolism. VII. Crystalline hydroxypyruvate reductase (D-glycerate dehydrogenase) (1968), J. Biol. Chem., 243, 2494-2499.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Br- | 2fold activation | Delftia acidovorans |  |
| Cl- | 2fold activation | Delftia acidovorans | |
| I- | 2.5fold activation | Delftia acidovorans | |
| NO3- | 2fold activation | Delftia acidovorans | |
| SO42- | 2fold activation | Delftia acidovorans | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Sodium bisulfite | 0.01 mM, 16% inhibition, 0.1 mM, 67% inhibition | Delftia acidovorans | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.015 | - |
NADPH | - |
Delftia acidovorans | |
| 0.13 | - |
Hydroxypyruvate | with 0.15 mM NADPH | Delftia acidovorans | |
| 0.24 | - |
NADH | - |
Delftia acidovorans | |
| 2.1 | - |
Hydroxypyruvate | with 0.15 mM NADH | Delftia acidovorans | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hydroxypyruvate + NAD(P)H | Delftia acidovorans | - |
D-glycerate + NAD(P)+ + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Delftia acidovorans | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 14.6 | - |
- |
Delftia acidovorans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hydroxypyruvate + NAD(P)H | - |
Delftia acidovorans | D-glycerate + NAD(P)+ + H+ | - |
? | |
| hydroxypyruvate + NAD(P)H | - |
Delftia acidovorans | D-glycerate + NAD(P)+ + H+ | - |
r | |
| hydroxypyruvate + NADH + H+ | - |
Delftia acidovorans | D-glycerate + NAD+ | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.3 | - |
sharp drop of activity below and above | Delftia acidovorans |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.3 | - |
sharp drop of activity below and above | Delftia acidovorans |
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Release 2023.1 (January 2023)
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