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Literature summary for 1.1.1.8 extracted from

  • Narise, S.
    Purification and biochemical properties of allelic forms of cytoplasmic glycerol-3-phosphate dehydrogenase from Drosophila virilis (1980), Biochim. Biophys. Acta, 615, 289-298.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dihydroxyacetone phosphate 0.5 mM, GPDHs more susceptible to inhibition Drosophila virilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km values of two further allelic isozymes, alpha-GPDHf and alpha-GPDHm Drosophila virilis
0.00526
-
NADH alpha-GPDHs Drosophila virilis
0.1003
-
NAD+ alpha-GPDHs, standard deviation 0.0041 mM Drosophila virilis
0.2144
-
dihydroxyacetone phosphate alpha-GPDHs, standard deviation 0.0215 mM Drosophila virilis
1.89
-
glycerol 3-phosphate alpha-GPDHs, standard deviation 0.25 mM Drosophila virilis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
gel filtration Drosophila virilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sn-glycerol 3-phosphate + NAD+ Drosophila virilis
-
dihydroxyacetone phosphate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Drosophila virilis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
3 allelic forms distinguishable by electrophoresis Drosophila virilis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
71.8
-
-
Drosophila virilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sn-glycerol 3-phosphate + NAD+
-
Drosophila virilis dihydroxyacetone phosphate + NADH + H+
-
r

Subunits

Subunits Comment Organism
dimer 2 * 35000-37000, SDS-PAGE Drosophila virilis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
isozyme GPDHf, activity falls off at temperature above 30°C Drosophila virilis
40
-
isozyme GPDHm and GPDHs Drosophila virilis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
35
-
most stable at pH 8, activity reduced, GPDHf to a greater extent Drosophila virilis

pH Range

pH Minimum pH Maximum Comment Organism
6 6.5 maximal activities of the three allelic forms are obtained within a pH range of 6.0-6.5 for dihydroxyacetone phosphate reduction Drosophila virilis
10 10.5 maximal activities of the three allelic forms are obtained within a pH range of 10.0-10.5 for glycerol 3-phosphate oxidation Drosophila virilis

pH Stability

pH Stability pH Stability Maximum Comment Organism
7
-
rate of inactivation increases below pH 7 Drosophila virilis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Drosophila virilis
NADH
-
Drosophila virilis