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Literature summary for 1.1.1.79 extracted from

  • Mdluli, K.; Booth, M.P.; Brady, R.L.; Rumsby, G.
    A preliminary account of the properties of recombinant human glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism (2005), Biochim. Biophys. Acta, 1753, 209-216.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli strain JM109 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Homo sapiens
0.011
-
NADPH 37°C Homo sapiens
0.011
-
NADPH pH 7.5, 37°C, recombinant enzyme Homo sapiens
0.058
-
Hydroxypyruvate 37°C, cofactor: NAPDH Homo sapiens
0.058
-
Hydroxypyruvate pH 7.5, 37°C, recombinant enzyme, with NADPH Homo sapiens
0.19
-
Hydroxypyruvate 37°C, cofactor: NADH Homo sapiens
0.19
-
Hydroxypyruvate pH 7.5, 37°C, recombinant enzyme, with NADH Homo sapiens
0.24
-
glyoxylate 37°C, cofactor: NADPH Homo sapiens
0.24
-
glyoxylate pH 7.5, 37°C, recombinant enzyme, with NADPH Homo sapiens
1
-
glyoxylate 37°C, cofactor: NADH Homo sapiens
1
-
glyoxylate pH 7.5, 37°C, recombinant enzyme, with NADH Homo sapiens
2.42
-
NADH 37°C Homo sapiens
2.42
-
NADH pH 7.5, 37°C, recombinant enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glyoxylate + NAD(P)H Homo sapiens the enzyme plays a protective role in detoxification of glyoxylate glycolate + NAD(P)+
-
?
hydroxypyruvate + NAD(P)H Homo sapiens
-
D-glycerate + NAD(P)+ + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
recombinant
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glyoxylate + NAD(P)H
-
Homo sapiens glycolate + NAD(P)+
-
?
glyoxylate + NAD(P)H the enzyme plays a protective role in detoxification of glyoxylate Homo sapiens glycolate + NAD(P)+
-
?
glyoxylate + NADH affinity for NADPH is lower than affinity for NADH Homo sapiens glycolate + NAD+
-
?
glyoxylate + NADPH
-
Homo sapiens glycolate + NADP+
-
?
hydroxypyruvate + NAD(P)H
-
Homo sapiens D-glycerate + NAD(P)+ + H+
-
?
hydroxypyruvate + NAD(P)H preferred substrate Homo sapiens D-glycerate + NAD(P)+ + H+
-
?
hydroxypyruvate + NADH affinity for NADPH is lower than affinity for NADH Homo sapiens D-glycerate + NAD+
-
?
hydroxypyruvate + NADPH
-
Homo sapiens D-glycerate + NADP+
-
?

Synonyms

Synonyms Comment Organism
glyoxylate reductase
-
Homo sapiens
GR/HPR
-
Homo sapiens
GRHPR
-
Homo sapiens
More the enzyme shows bifunctionality also performing the reaction of hydroxypyruvate reductase, EC 1.1.1.81 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
27
-
glyoxylate 37°C, cofactor: NADPH Homo sapiens
27
-
glyoxylate pH 7.5, 37°C, recombinant enzyme, with NADPH Homo sapiens
38
-
Hydroxypyruvate 37°C, cofactor: NAPDH Homo sapiens
38
-
Hydroxypyruvate pH 7.5, 37°C, recombinant enzyme, with NADPH Homo sapiens
65
-
Hydroxypyruvate 37°C, cofactor: NADH Homo sapiens
65
-
Hydroxypyruvate pH 7.5, 37°C, recombinant enzyme, with NADH Homo sapiens
67
-
glyoxylate 37°C, cofactor: NADH Homo sapiens
67
-
glyoxylate pH 7.5, 37°C, recombinant enzyme, with NADH Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens
NADH higher affinity for NADPH Homo sapiens
NADPH preferred cofactor Homo sapiens
NADPH lower affinity for NADH Homo sapiens