Literature summary for 1.1.1.69 extracted from

Shi, Z.; Xuan, C.; Han, H.; Cheng, X.; Wang, J.; Feng, Y.; Srinivas, S.; Lu, G.; Gao, G.F.
Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division (2014), Protein Cell, 5, 761-769.

Search for more literature for 1.1.1.69

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Streptococcus suis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-gluconate + NAD+	Streptococcus suis	-	5-dehydro-D-gluconate + NADH + H+	-	r
D-gluconate + NAD+	Streptococcus suis 05ZYH33	-	5-dehydro-D-gluconate + NADH + H+	-	r
D-gluconate + NADP+	Streptococcus suis	-	5-dehydro-D-gluconate + NADPH + H+	-	r
D-gluconate + NADP+	Streptococcus suis 05ZYH33	-	5-dehydro-D-gluconate + NADPH + H+	-	r

Organism

Organism	UniProt	Comment	Textmining
Streptococcus suis	-	-	-
Streptococcus suis 05ZYH33	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
glutathione Sepharose column chromatography and Superdex 200 gel filtration	Streptococcus suis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-gluconate + NAD+	-	Streptococcus suis	5-dehydro-D-gluconate + NADH + H+	-	r
D-gluconate + NAD+	-	Streptococcus suis 05ZYH33	5-dehydro-D-gluconate + NADH + H+	-	r
D-gluconate + NADP+	-	Streptococcus suis	5-dehydro-D-gluconate + NADPH + H+	-	r
D-gluconate + NADP+	-	Streptococcus suis 05ZYH33	5-dehydro-D-gluconate + NADPH + H+	-	r

Synonyms

Synonyms	Comment	Organism
GA5DH	-	Streptococcus suis

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Streptococcus suis
NADP+	-	Streptococcus suis

General Information

General Information	Comment	Organism
physiological function	the enzyme prevents the formation of ectopic Z rings during Streptococcus suis cell division and plays a role in septum constriction	Streptococcus suis

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)