Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Aspergillus fumigatus | |
AMP | - |
Aspergillus fumigatus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
NADH | pH 7.1, 25°C | Aspergillus fumigatus | |
0.11 | - |
NAD+ | pH 7.1, 25°C | Aspergillus fumigatus | |
0.6 | - |
D-fructose | pH 7.1, 25°C | Aspergillus fumigatus | |
1.7 | - |
D-xylulose | pH 7.1, 25°C | Aspergillus fumigatus | |
13 | - |
D-mannitol | pH 10.0, 25°C | Aspergillus fumigatus | |
163 | - |
D-arabinitol | pH 10.0, 25°C | Aspergillus fumigatus | |
680 | - |
L-sorbitol | pH 10.0, 25°C | Aspergillus fumigatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-fructose + NADH + H+ | Aspergillus fumigatus | - |
D-mannitol + NAD+ | - |
r | |
D-mannitol + NAD+ | Aspergillus fumigatus | free energy profiles for the enzymatic reaction suggest that enzyme primarily acts in D-mannitol oxidation | D-fructose + NADH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | Q4WQY4 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
D-mannitol + NAD+ = D-fructose + NADH + H+ | binding of substrate and NAD(H) is random for both D-mannitol oxidation and D-fructose reduction. Hydride transfer is rate-determining for D-fructose reduction. Product release steps control the maximum rates in the other direction of the enzymatic reaction | Aspergillus fumigatus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-arabinitol + NAD+ | - |
Aspergillus fumigatus | D-xylulose + NADH + H+ | - |
r | |
D-fructose + NADH + H+ | - |
Aspergillus fumigatus | D-mannitol + NAD+ | - |
r | |
D-mannitol + NAD+ | free energy profiles for the enzymatic reaction suggest that enzyme primarily acts in D-mannitol oxidation | Aspergillus fumigatus | D-fructose + NADH + H+ | - |
r | |
D-xylulose + NADH + H+ | - |
Aspergillus fumigatus | D-arabinitol + NAD+ | - |
? | |
L-sorbitol + NAD+ | - |
Aspergillus fumigatus | L-sorbose + NADH + H+ | - |
r | |
L-sorbose + NADH + H+ | - |
Aspergillus fumigatus | L-sorbitol + NAD+ | - |
r | |
additional information | a D-arabo configuration is required for a polyol substrate to become reactive. The C2 (R) configuration as in mannitol is preferred over the C2 (S) configuration as in D-sorbitol | Aspergillus fumigatus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
M2DH | - |
Aspergillus fumigatus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
half-life 3.6 h | Aspergillus fumigatus |
30 | - |
half-life 0.42 h | Aspergillus fumigatus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
60 | - |
L-sorbitol | pH 10.0, 25°C | Aspergillus fumigatus | |
64 | - |
D-xylulose | pH 7.1, 25°C | Aspergillus fumigatus | |
86 | - |
D-fructose | pH 7.1, 25°C | Aspergillus fumigatus | |
162 | - |
D-arabinitol | pH 10.0, 25°C | Aspergillus fumigatus | |
212 | - |
D-mannitol | pH 10.0, 25°C | Aspergillus fumigatus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | only trace activity for utilization of NADP+ | Aspergillus fumigatus | |
NAD+ | - |
Aspergillus fumigatus | |
NADH | - |
Aspergillus fumigatus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2.9 | - |
AMP | pH 7.1, 25°C, reduction of fructose | Aspergillus fumigatus | |
4.8 | - |
AMP | pH 7.1, 25°C, oxidation of mannitol | Aspergillus fumigatus | |
5.6 | - |
ADP | pH 7.1, 25°C, reduction of fructose | Aspergillus fumigatus | |
5.7 | - |
ADP | pH 7.1, 25°C, oxidation of mannitol | Aspergillus fumigatus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.088 | - |
L-sorbitol | pH 10.0, 25°C | Aspergillus fumigatus | |
0.99 | - |
D-arabinitol | pH 10.0, 25°C | Aspergillus fumigatus | |
1.1 | - |
L-sorbose | pH 7.1, 25°C | Aspergillus fumigatus | |
17 | - |
D-mannitol | pH 10.0, 25°C | Aspergillus fumigatus | |
39 | - |
D-xylulose | pH 7.1, 25°C | Aspergillus fumigatus | |
140 | - |
D-fructose | pH 7.1, 25°C | Aspergillus fumigatus |