Cloned (Comment) | Organism |
---|---|
expression in HeLa cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(3-bromo-4-hydroxybenzylidene)-3-(4-fluorophenyl)-2-thioxo-1,3-oxazolidin-4-one | strong inhibitory activity on isoform 3beta-HSD3 | Homo sapiens | |
5-(3-bromo-4-hydroxybenzylidene)-3-(4-methylphenyl)-2-thioxo-1,3-oxazolidin-4-one | strong inhibitory activity on isoform 3beta-HSD3 | Homo sapiens | |
5-(3-chloro-5-fluoro-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-oxazolidin-4-one | strong inhibitory activity on isoform 3beta-HSD3 | Homo sapiens | |
5-(3-fluoro-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-tioxo-1,3-oxazolidin-4-one | strong inhibitory activity on isoform 3beta-HSD3 | Homo sapiens | |
5-[3,5-dichloro-4-(phosphonoxy)benzylidene]-3-(4-methoxyphenyl)-2-thioxo-1,3-oxazolidin-4-one | strong inhibitory activity on isoform 3beta-HSD3 | Homo sapiens | |
5-[3,5-dichloro-4-(phosphonoxy)benzylidene]-3-(4-methoxyphenyl)-2-thioxo-1,3-oxazolidin-4-one | strong inhibitory activity on isoform 3beta-HSD3. When administered orally at a high dose of 100 mg/kg, compound shows approximately two times more potent testosterone-lowering effect against a positive control in the luteinizing hormone-releasing hormone-induced T production assay. The T-lowering effect continues at ca 10% level of control over 4 h after administration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P37058 | - |
- |
Rattus norvegicus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD3 | - |
Rattus norvegicus |
17beta-HSD3 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
cell-based assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-[3,5-dichloro-4-(phosphonoxy)benzylidene]-3-(4-methoxyphenyl)-2-thioxo-1,3-oxazolidin-4-one | |
0.000002 | - |
cell-based assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-(3-bromo-4-hydroxybenzylidene)-3-(4-fluorophenyl)-2-thioxo-1,3-oxazolidin-4-one | |
0.000002 | - |
cell-based assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-(3-bromo-4-hydroxybenzylidene)-3-(4-methylphenyl)-2-thioxo-1,3-oxazolidin-4-one | |
0.000002 | - |
cell-based assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-(3-fluoro-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-tioxo-1,3-oxazolidin-4-one | |
0.000002 | - |
cell-based assay, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-(3-chloro-5-fluoro-4-hydroxybenzylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-oxazolidin-4-one |