Literature summary for 1.1.1.64 extracted from

Day, J.M.; Tutill, H.J.; Foster, P.A.; Bailey, H.V.; Heaton, W.B.; Sharland, C.M.; Vicker, N.; Potter, B.V.; Purohit, A.; Reed, M.J.
Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (2009), Mol. Cell. Endocrinol., 301, 251-258.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in LNCaP cells and in an 293-EBNA-based cell line	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
STX-2171	-	Homo sapiens
STX-2622	-	Homo sapiens
STX-2624	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
prostate cancer cell line	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
androst-4-ene-3,17-dione + NADPH + H+	-	Homo sapiens	testosterone + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
17beta-HSD3	-	Homo sapiens
17beta-hydroxysteroid dehydrogenase type 3	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000201	-	at 37°C	Homo sapiens	STX-2622
0.000383	-	at 37°C	Homo sapiens	STX-2171
0.000441	-	at 37°C	Homo sapiens	STX-2624

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Release 2023.1 (January 2023)