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Literature summary for 1.1.1.62 extracted from
- AKR1C3 (type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase) Roles in malignancy and endocrine disorders (2019), Mol. Cell. Endocrinol., 489, 82-91 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P42330 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 17beta-HSD | - |
Homo sapiens |
| AKR1C3 | - |
Homo sapiens |
| type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | by acting as a 17-ketosteroid reductase, AKR1C3 produces potent androgens in peripheral tissues which activate the androgen receptor or act as substrates for aromatase. AKR1C3 is implicated in the production of androgens in castration-resistant prostate cancer and polycystic ovarian syndrome and is implicated in the production of aromatase substrates in breast cancer | Homo sapiens |
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Release 2023.1 (January 2023)
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