Literature summary for 1.1.1.62 extracted from

Aka, J.; Calvo, E.; Lin, S.
Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1 (2017), Mol. Cell. Endocrinol., 439, 175-186 .

Search for more literature for 1.1.1.62

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14061	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
17beta-HSD1	-	Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	knockdown of 17beta-HSD1 gene, HSD17B1, modulates the transcript profile of the hormone-dependent breast cancer cell line T47D, T47D, with 105 genes regulated 1.5 fold or higher in estradiol-independent manner	Homo sapiens
malfunction	knockdown of 17beta-HSD1 gene, HSD17B1, modulates the transcript profile of the hormone-dependent breast cancer cell line T47D, with 105 genes regulated 1.5fold or higher in estradiol-independent manner. Genes that are primarily involved in the cell cycle progression, such as the cyclin A2 gene, CCNA2, are generally down-regulated whereas genes involved in apoptosis and cell death, including the pro-apoptotic gene XAF1, IFIH1 and FGF12, are upregulated by 17beta-HSD1 knockdown	Homo sapiens
physiological function	17beta-HSD1 may be involved in oncogenesis by favoring antiapoptosis pathway in breast cancer cells	Homo sapiens
physiological function	the enzyme 17beta-HSD1 may be involved in oncogenesis by favoring antiapoptosis pathway in breast cancer cells and correborates with its previously shown role in increasing breast cancer cell proliferation. The gene regulation occurring in steroid-deprived conditions shows that 17beta-HSD1 can modulate endogenous gene expression in steroid-independent manners	Homo sapiens
physiological function	the enzyme increases breast cancer cell proliferation via a dual effect on 17-beta-estradiol and 5alpha-dihydrotestosterone levels and impacts gene expression and protein profile of breast cancer cells cultured in 17-beta-estradiol-contained medium	Homo sapiens

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Release 2023.1 (January 2023)