Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
expression in Escherichia coli BL21 DE3 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P56937 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
breast cancer cell | the inhibition of the enzyme (17beta-HSD7) constitutes the basis of breast cancer cell proliferation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NADPH + H+ | kinetics demonstrates positive cooperativity | Homo sapiens | ? + NADP+ | - |
? | |
dihydrotestosterone + NADPH + H+ | the enzyme show positive cooperativity | Homo sapiens | 5alpha-androstane-3beta,17beta-diol + NADP+ | - |
? | |
estrone + NADPH + H+ | kinetics demonstrates positive cooperativity | Homo sapiens | estradiol + NADP+ | - |
? | |
estrone + NADPH + H+ | the enzyme show positive cooperativity | Homo sapiens | 17beta-estradiol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD7 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase type 7 | - |
Homo sapiens |
7beta-HSD7 | - |
Homo sapiens |
reductive 17beta-hydroxysteroid dehydrogenase type 7 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0063 | - |
estrone | pH 7.5, 37°C | Homo sapiens | |
0.0153 | - |
5alpha-dihydrotestosterone | pH 7.5, 37°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
drug target | inhibition of 17beta-HSD7 constitutes the basis of breast cancer cell proliferation | Homo sapiens |
metabolism | synergistic function in estrogen and androgen control | Homo sapiens |