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Literature summary for 1.1.1.62 extracted from

  • Theriault, J.F.; Lin, S.X.
    The dual sex hormone specificity for human reductive 17beta-hydroxysteroid dehydrogenase type 7 Synergistic function in estrogen and androgen control (2019), J. Steroid Biochem. Mol. Biol., 186, 61-65 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens
expression in Escherichia coli BL21 DE3 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P56937
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
breast cancer cell the inhibition of the enzyme (17beta-HSD7) constitutes the basis of breast cancer cell proliferation Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-dihydrotestosterone + NADPH + H+ kinetics demonstrates positive cooperativity Homo sapiens ? + NADP+
-
?
dihydrotestosterone + NADPH + H+ the enzyme show positive cooperativity Homo sapiens 5alpha-androstane-3beta,17beta-diol + NADP+
-
?
estrone + NADPH + H+ kinetics demonstrates positive cooperativity Homo sapiens estradiol + NADP+
-
?
estrone + NADPH + H+ the enzyme show positive cooperativity Homo sapiens 17beta-estradiol + NADP+
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD7
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase type 7
-
Homo sapiens
7beta-HSD7
-
Homo sapiens
reductive 17beta-hydroxysteroid dehydrogenase type 7
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0063
-
estrone pH 7.5, 37°C Homo sapiens
0.0153
-
5alpha-dihydrotestosterone pH 7.5, 37°C Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
drug target inhibition of 17beta-HSD7 constitutes the basis of breast cancer cell proliferation Homo sapiens
metabolism synergistic function in estrogen and androgen control Homo sapiens