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Literature summary for 1.1.1.62 extracted from

  • Verma, M.; Miki, Y.; Abe, K.; Suzuki, T.; Niikawa, H.; Suzuki, S.; Kondo, T.; Sasano, H.
    Intratumoral localization and activity of 17beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer: A potent prognostic factor (2013), J. Transl. Med., 11, 167-177.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.62

Application

Application Comment Organism
medicine 17betaHSD1 is an important prognostic factor in non-small cell lung carcinoma, NSCLC, patients and targeting 17betaHSD1 activity may further improve the clinical response in estrogen responsive NSCLC patients Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene HSD18B1, quantitative RT-PCR expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information 72 h treatment with 17betaHSD1 siRNA 2 significantly reduces the endogenous 17betaHSD1 expression in both A-549 and LK-87 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone + NADPH + H+ Homo sapiens
-
 17beta-estradiol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14061
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
LK-87 cell
-
 Homo sapiens
-
non-small cell lung carcinoma cell NSCLC, immunihostichemic enzyme analysis: higher 17betaHSD1 immunoreactivity tends to be positively associated with aromatase and tumor stage. A higher 17betaHSD1 immunoreactivity is also significantly associated with lower intratumoral estrone concentration and a higher intratumoral estradiol/estrone concentration ratio. On the other hand a higher 17betaHSD2 immunoreactivity is significantly associated with higher intratumoral estrone concentration Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone + NADPH + H+
-
 Homo sapiens 17beta-estradiol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
17beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens
17betaHSD1
-
 Homo sapiens
HSD17B1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens aromatase inhibitor treatment results in 17betaHSD1 upregulation in both A-549 and LK-87 cells up

General Information

General Information Comment Organism
malfunction estrone treatment in 17betaHSD1 positive NSCLC cells, A-549 and LK-87, results in estradiol production and enhances cell proliferation, which is abrogated effectively by 17betaHSD1 siRNA knockdown Homo sapiens
physiological function estrone treatment in 17betaHSD1 positive NSCLC cells, A-549 and LK-87, results in estradiol production and enhances cell proliferation, which is abrogated effectively by 17betaHSD1 siRNA knockdown Homo sapiens