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Literature summary for 1.1.1.62 extracted from

  • Lima, D.; MacHado, A.; Reis-Henriques, M.; Rocha, E.; Santos, M.; Castro, L.
    Cloning and expression analysis of the 17beta hydroxysteroid dehydrogenase type 12 (HSD17B12) in the neogastropod Nucella lapillus (2013), J. Steroid Biochem. Mol. Biol., 134, 8-14.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Nucella lapillus K7S9E9
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Source Tissue

Source Tissue Comment Organism Textmining
digestive gland
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Nucella lapillus
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digestive gland ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland Nucella lapillus
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kidney
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Nucella lapillus
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kidney ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland Nucella lapillus
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additional information ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland Nucella lapillus
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additional information NlHsd17b12 is ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland, a pattern consistent with an involvement in lipid metabolism, detailed tissue distribution through quantitative PCR Nucella lapillus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NAD(P)+
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Nucella lapillus estrone + NAD(P)H + H+
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?

Synonyms

Synonyms Comment Organism
17-beta-hydroxysteroid dehydrogenase type 12
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Nucella lapillus
HSD17B12
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Nucella lapillus
NlHsd17b12
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Nucella lapillus

Cofactor

Cofactor Comment Organism Structure
NAD+
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Nucella lapillus
NADH
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Nucella lapillus
NADP+
-
Nucella lapillus
NADPH
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Nucella lapillus

Expression

Organism Comment Expression
Nucella lapillus exposure to tributyltin chloride at 100 ng Sn2+/l causes a decrease in mRNA levels in digestive gland, after one and two months, while no effect is observed in gonads down

General Information

General Information Comment Organism
evolution HSD17B12 is a member of the hydroxysteroid dehydrogenase superfamily, a multifunctional group of enzymes involved in the metabolism of steroids, retinoids, bile and fatty acids Nucella lapillus
physiological function that in mollusks, as in mammals, this enzyme is likely to be involved in lipid metabolism Nucella lapillus