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Literature summary for 1.1.1.62 extracted from

  • Day, J.M.; Foster, P.A.; Tutill, H.J.; Parsons, M.F.; Newman, S.P.; Chander, S.K.; Allan, G.M.; Lawrence, H.R.; Vicker, N.; Potter, B.V.; Reed, M.J.; Purohit, A.
    17beta-Hydroxysteroid dehydrogenase type 1, and not type 12, is a target for endocrine therapy of hormone-dependent breast cancer (2008), Int. J. Cancer, 122, 1931-1940.
    View publication on PubMed
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Application

Application Comment Organism
medicine 17beta-HSD1 inhibitors such as STX1040 may provide a treatment for hormone-dependent breast cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the complete 17beta-HSD1 (HSD17B131) and 17beta-HSD12 (HSD17B12) cDNA sequences are cloned into the pCEP4 expression vector for expression in 293-EBNA cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
STX1040
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14061
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone + NAD(P)H + H+
-
 Homo sapiens estradiol-17beta + NAD(P)+
-
 ?

Synonyms

Synonyms Comment Organism
17beta-HSD1
-
 Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000027
-
-
 Homo sapiens STX1040