Application | Comment | Organism |
---|---|---|
drug development | several 17beta-HSD isozymes are targets for drug development with importance in cancer, metabolic diseases, neurodegeneration and possibly immunity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
chromosomal localizations of isozymes, DNA and amino acid sequence determination and analysis of isozymes 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, overview | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
17beta-HSD14 in ternary complex with NADP+ and estradiol, modelling | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | isozymes 17beta-HSD2, 17beta-HSD3, and 17beta-HSD7 | Homo sapiens | 5783 | - |
mitochondrion | isozyme 17beta-HSD10 | Homo sapiens | 5739 | - |
soluble | isozyme 17beta-HSD14, 17beta-HSD5, and 17beta-HSD1 | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NADPH | Homo sapiens | the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites | 17beta-estradiol + NADP+ | - |
r | |
estronesulfate + NADPH | Homo sapiens | - |
17beta-estradiolsulfate + NADP+ | - |
r | |
additional information | Homo sapiens | the isozymes constitute by showing different properties a complex system ensuring cell-specific adaptation and regulation of sex steroid hormone levels, isozyme 17beta-HSD1 is the major determinant of peripheral and gonadal estradiol synthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
several isozymes, encoded by different genes | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ | active site structure of isozymes 17beta-HSD1 and 17beta-HSD14 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gonad | - |
Homo sapiens | - |
liver | 17beta-HSD8 | Homo sapiens | - |
ovary | 17beta-HSD8 in cumulus cells, not in granulosa and luteal cells, vice versa for isozymes 17beta-HSD1 and 17beta-HSD7 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NADPH | the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites | Homo sapiens | 17beta-estradiol + NADP+ | - |
r | |
estrone + NADPH | substrate of e.g. isozyme 17beta-HSD3, 17beta-HSD8, and 17beta-HSD14 | Homo sapiens | 17beta-estradiol + NADP+ | - |
r | |
estronesulfate + NADPH | - |
Homo sapiens | 17beta-estradiolsulfate + NADP+ | - |
r | |
additional information | the isozymes constitute by showing different properties a complex system ensuring cell-specific adaptation and regulation of sex steroid hormone levels, isozyme 17beta-HSD1 is the major determinant of peripheral and gonadal estradiol synthesis | Homo sapiens | ? | - |
? | |
additional information | 17beta-HSD isozymes differ in their expression pattern, nucleotide cofactor preferences, steroid substrate specificity, and subcellular localization, detailed overview, substrate are androgens, estrogens, cholesterol, progestins, and eicosanoids, isozyme 17beta-HSD3 also shows 3beta-hydroxysteroid dehydrogenase, EC 1.1.1.51, isozyme 17beta-HSD8 also shows, to a lessser extent, NAD+-dependent testosterone oxidation to androstenedione, EC 1.1.1.63 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
More | 17beta-HSDs belong to the aldo-keto reductase family or the short-chain dehydrogenase family, overview | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |