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Literature summary for 1.1.1.62 extracted from

  • Moeller, G.; Adamski, J.
    Multifunctionality of human 17beta-hydroxysteroid dehydrogenases (2006), Mol. Cell. Endocrinol., 248, 47-55.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isozyme 17beta-HSD1 Homo sapiens 5829
-
peroxisome isozyme 17beta-HSD4 Homo sapiens 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-estradiol + NADP+ Homo sapiens
-
estrone + NADPH
-
?
estrone + NADPH Homo sapiens isozyme 17beta-HSD1 17beta-estradiol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes 17beta-HSD4 and 17beta-HSD1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver isozyme 17beta-HSD4 Homo sapiens
-
ovary isozyme 17beta-HSD1 Homo sapiens
-
placenta isozyme 17beta-HSD1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NADP+
-
Homo sapiens estrone + NADPH
-
?
17beta-estradiol + NADP+ isozyme 17beta-HSD4 Homo sapiens estrone + NADPH
-
?
estrone + NADPH isozyme 17beta-HSD1 Homo sapiens 17beta-estradiol + NADP+
-
?
additional information human 17beta-hydroxysteroid dehydrogenases are multifunctional enzymes, isozyme 17beta-HSD4 also performs beta-oxidation of branched fatty acids, like pristanic acid, and in bile acid synthesis, e.g. of di- and trihydroxycholestanoic acids, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD1
-
Homo sapiens
17beta-HSD4
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens