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Literature summary for 1.1.1.62 extracted from

  • Liu, H.; Robert, A.; Luu-The, V.
    Cloning and characterization of human form 2 type 7 17beta-hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme (2005), J. Steroid Biochem. Mol. Biol., 94, 173-179.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-dihydrotestosterone + NADP+ Homo sapiens the enzyme could play a critical role in estrogen-sensitive cells, since it inactivates 5alpha-dihydrotestosterone that generally shows antagonistic effect in the cells 5alpha-androstan-3,17-dione + NADPH
-
?
estrone + NAD(P)H Homo sapiens the enzyme produces active estradiol for cell proliferation estradiol-17beta + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5MGS6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
placenta
-
Homo sapiens
-
prostate gland
-
Homo sapiens
-
uterus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-dihydrotestosterone + NADP+
-
Homo sapiens 5alpha-androstan-3,17-dione + NADPH
-
?
5alpha-dihydrotestosterone + NADP+ the enzyme could play a critical role in estrogen-sensitive cells, since it inactivates 5alpha-dihydrotestosterone that generally shows antagonistic effect in the cells Homo sapiens 5alpha-androstan-3,17-dione + NADPH
-
?
estrone + NAD(P)H the enzyme produces active estradiol for cell proliferation Homo sapiens estradiol-17beta + NAD(P)+
-
?
estrone + NAD(P)H + H+
-
Homo sapiens estradiol-17beta + NAD(P)+
-
?
zymosterone + NAD(P)H
-
Homo sapiens zymosterol + NAD(P)+
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD7 2
-
Homo sapiens
form 2 type 7 17beta-hydroxysteroid dehydrogenase
-
Homo sapiens