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Literature summary for 1.1.1.62 extracted from

  • Pollow, K.; Elger, W.; Hesslinger, H.; Pollow, B.
    Purification and properties of the soluble 17beta-hydroxysteroid dehydrogenase of rabbit uterus (1979), Z. Naturforsch. C, 34, 726-737.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
androstenedione
-
Oryctolagus cuniculus
androsterone
-
Oryctolagus cuniculus
Cu2+ CuSO4 Oryctolagus cuniculus
estrone
-
Oryctolagus cuniculus
Mg2+ MgCl2 Oryctolagus cuniculus
PCMB
-
Oryctolagus cuniculus
progesterone
-
Oryctolagus cuniculus
testosterone
-
Oryctolagus cuniculus
Zn2+ ZnCl2 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0416
-
estradiol cosubstrate NAD+ Oryctolagus cuniculus
0.0437
-
estradiol cosubstrate NAD+ Oryctolagus cuniculus
0.357
-
NAD+
-
Oryctolagus cuniculus
0.37
-
NADP+
-
Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31000
-
2 * 31000, SDS-PAGE Oryctolagus cuniculus
64000
-
gel filtration Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
uterus
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estradiol-17beta + NAD+
-
Oryctolagus cuniculus estrone + NADH
-
r
estradiol-17beta + NADP+
-
Oryctolagus cuniculus estrone + NADPH
-
r
estrone + NADH
-
Oryctolagus cuniculus estradiol-17beta + NAD+
-
r
estrone + NADPH + H+
-
Oryctolagus cuniculus estradiol-17beta + NADP+
-
r
testosterone + NADP+ lower activity than with estradiol 17beta Oryctolagus cuniculus 4-androstene-3,17-dione + NADPH + H+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 31000, SDS-PAGE Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
43
-
formation of estrone Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5 6.5 reduction of estrone Oryctolagus cuniculus
9.5 10.5 oxidation of estradiol-17beta Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NAD+ cofactor Oryctolagus cuniculus
NADH cofactor Oryctolagus cuniculus
NADP+ cofactor Oryctolagus cuniculus
NADPH cofactor Oryctolagus cuniculus