Inhibitors | Comment | Organism | Structure |
---|---|---|---|
androstenedione | - |
Oryctolagus cuniculus | |
androsterone | - |
Oryctolagus cuniculus | |
Cu2+ | CuSO4 | Oryctolagus cuniculus | |
estrone | - |
Oryctolagus cuniculus | |
Mg2+ | MgCl2 | Oryctolagus cuniculus | |
PCMB | - |
Oryctolagus cuniculus | |
progesterone | - |
Oryctolagus cuniculus | |
testosterone | - |
Oryctolagus cuniculus | |
Zn2+ | ZnCl2 | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0416 | - |
estradiol | cosubstrate NAD+ | Oryctolagus cuniculus | |
0.0437 | - |
estradiol | cosubstrate NAD+ | Oryctolagus cuniculus | |
0.357 | - |
NAD+ | - |
Oryctolagus cuniculus | |
0.37 | - |
NADP+ | - |
Oryctolagus cuniculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
31000 | - |
2 * 31000, SDS-PAGE | Oryctolagus cuniculus |
64000 | - |
gel filtration | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
uterus | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Oryctolagus cuniculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estradiol-17beta + NAD+ | - |
Oryctolagus cuniculus | estrone + NADH | - |
r | |
estradiol-17beta + NADP+ | - |
Oryctolagus cuniculus | estrone + NADPH | - |
r | |
estrone + NADH | - |
Oryctolagus cuniculus | estradiol-17beta + NAD+ | - |
r | |
estrone + NADPH + H+ | - |
Oryctolagus cuniculus | estradiol-17beta + NADP+ | - |
r | |
testosterone + NADP+ | lower activity than with estradiol 17beta | Oryctolagus cuniculus | 4-androstene-3,17-dione + NADPH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 31000, SDS-PAGE | Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
43 | - |
formation of estrone | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | 6.5 | reduction of estrone | Oryctolagus cuniculus |
9.5 | 10.5 | oxidation of estradiol-17beta | Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | cofactor | Oryctolagus cuniculus | |
NADH | cofactor | Oryctolagus cuniculus | |
NADP+ | cofactor | Oryctolagus cuniculus | |
NADPH | cofactor | Oryctolagus cuniculus |