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Literature summary for 1.1.1.53 extracted from
- Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2 (2012), Mol. Cell. Endocrinol., 349, 202-213.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.142 | - |
cortisone | pH 7.3, 28°C | Danio rerio |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Danio rerio | 5783 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | in adult tissues, isoform 20beta-HSD type 2 shows a ubiquitous expression pattern with some minor sex-specific differences | Danio rerio | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cortisone + NADPH + H+ | - |
Danio rerio | 20beta-hydroxycortisone + NADP+ | i.e. 4-pregnen-17alpha,20beta,21-triol-3,11-dione | ? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not active: NADH | Danio rerio | |
| NADPH | - |
Danio rerio | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Danio rerio | expressed during embryonic development | additional information |
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Release 2023.1 (January 2023)
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