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Literature summary for 1.1.1.53 extracted from

  • Sweet, F.; Samant, B.R.
    Bifunctional enzyme activity at the same active site: study of 3alpha and 20beta activity by affinity alkylation of 3alpha, 20beta-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids (1980), Biochemistry, 19, 978-986.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
17-Acetoxyprogesterone
-
Streptomyces exfoliatus
17-Bromoacetoxyprogesterone
-
Streptomyces exfoliatus
5alpha-Dihydrotestosterone bromoacetate
-
Streptomyces exfoliatus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0039
-
progesterone
-
Streptomyces exfoliatus
0.0045
-
5alpha-pregnane-3,20-dione
-
Streptomyces exfoliatus
0.0105
-
17-hydroxyprogesterone
-
Streptomyces exfoliatus
0.02
-
6beta-[bromoacetoxy]-progesterone
-
Streptomyces exfoliatus
0.318
-
cortisone
-
Streptomyces exfoliatus

Organism

Organism UniProt Comment Textmining
Streptomyces exfoliatus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Streptomyces exfoliatus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17-hydroxyprogesterone + NADH
-
Streptomyces exfoliatus ?
-
?
17alpha-hydroxyprogesterone + NADPH + H+
-
Streptomyces exfoliatus 17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
?
5alpha-pregnane-3,20-dione + NADH
-
Streptomyces exfoliatus ?
-
?
6beta-(bromoacetoxy)-progesterone + NADH
-
Streptomyces exfoliatus ?
-
?
6beta-[bromoacetoxy]-progesterone + NAD+
-
Streptomyces exfoliatus ?
-
r
cortisone + NAD(P)H i.e. 17beta,21-dihydroxy-pregn-4-ene-3,11,20-trione Streptomyces exfoliatus 17alpha,20beta,21-trihydroxy-pregn-4-ene-3,11-dione + NAD(P)+
-
?
progesterone + NAD(P)H
-
Streptomyces exfoliatus 20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+
-
?

pH Stability

pH Stability pH Stability Maximum Comment Organism
9
-
in Tris-buffer, best value for stability Streptomyces exfoliatus