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Literature summary for 1.1.1.51 extracted from

  • Hilborn, E.; Stal, O.; Jansson, A.
    Estrogen and androgen-converting enzymes 17beta-hydroxysteroid dehydrogenase and their involvement in cancer with a special focus on 17beta-hydroxysteroid dehydrogenase type 1, 2, and breast cancer (2017), Oncotarget, 8, 30552-30562 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.51

Application

Application Comment Organism
diagnostics a high HSD17B1 to HSD17B2 ratio, as well as high HSD17B1 on its own is associated with worse prognosis and increased risk of recurrence in patients with ERalpha-positive tumors. An increased copy number of the HSD17B1 gene is correlated with decreased breast cancer survival Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14061
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone + NAD(P)H + H+
-
 Homo sapiens androstendiol + NAD(P)+
-
 ?
estrone + NAD(P)H + H+
-
 Homo sapiens 17beta-estradiol + NAD(P)+
-
 ?

Synonyms

Synonyms Comment Organism
17beta-HSD1
-
 Homo sapiens
17beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in non-small cell lung cancer (NSCLC) the expression of HSD17B1 is increased as compared with healthy tissue up

General Information

General Information Comment Organism
drug target the ratio of HSD17B1 to HSD17B2 is a good indicator of tamoxifen treatment benefit, as post-menopausal patients with tumors expressing a high HSD17B1/HSD17B2 protein ratio have less benefit from tamoxifen treatment Homo sapiens
physiological function the expression of 17beta-hydroxysteroid dehydrogenase 1 and 2 alone and in combination predicts outcome of patients with breast cancer Homo sapiens