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Literature summary for 1.1.1.51 extracted from

  • Ernst, M.; de Padua, R.M.; Herl, V.; Mueller-Uri, F.; Kreis, W.
    Expression of 3beta-HSD and P5betaR, genes respectively coding for Delta5-3beta-hydroxysteroid dehydrogenase and progesterone 5beta-reductase, in leaves and cell cultures of Digitalis lanata EHRH (2010), Planta Med., 76, 923-927.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene 3bhsd, quantitative real-time PCR expression analysis Digitalis lanata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5beta-pregnan-3,20-dione + NADPH + H+ Digitalis lanata
-
5beta-pregnane-3beta-ol-20-one + NADP+
-
?
5beta-pregnan-3,20-dione + NADPH + H+ Digitalis lanata EHRH
-
5beta-pregnane-3beta-ol-20-one + NADP+
-
?
pregnenolone + NADPH + H+ Digitalis lanata
-
isoprogesterone + NADP+
-
?
pregnenolone + NADPH + H+ Digitalis lanata EHRH
-
isoprogesterone + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Digitalis lanata Q93Y47
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell suspension culture
-
Digitalis lanata
-
K3OHD cell
-
Digitalis lanata
-
leaf
-
Digitalis lanata
-
additional information the enzyme is also expressed in cardenolide-free tissues of cardenolide-containing plants Digitalis lanata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5beta-pregnan-3,20-dione + NADPH + H+
-
Digitalis lanata 5beta-pregnane-3beta-ol-20-one + NADP+
-
?
5beta-pregnan-3,20-dione + NADPH + H+
-
Digitalis lanata EHRH 5beta-pregnane-3beta-ol-20-one + NADP+
-
?
pregnenolone + NADPH + H+
-
Digitalis lanata isoprogesterone + NADP+
-
?
pregnenolone + NADPH + H+
-
Digitalis lanata EHRH isoprogesterone + NADP+
-
?

Synonyms

Synonyms Comment Organism
3beta-HSD
-
Digitalis lanata
3beta-hydroxysteroid dehydrogenase
-
Digitalis lanata

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Digitalis lanata

General Information

General Information Comment Organism
physiological function key enzyme in cardenolide biosynthesis Digitalis lanata