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Literature summary for 1.1.1.51 extracted from

  • Lukacik, P.; Kavanagh, K.L.; Oppermann, U.
    Structure and function of human 17beta-hydroxysteroid dehydrogenases (2006), Mol. Cell. Endocrinol., 248, 61-71.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum the hydrophobic 17beta-HSD3 is membrane-bound through an N-terminal transmembrane domain Homo sapiens 5783
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-androstene-3,17-dione + NADPH + H+ Homo sapiens isozymes 17beta-HSD3 and 17beta-HSD5 testosterone + NADP+
-
r
5-androstenedione + NADPH Homo sapiens isozyme 17beta-HSD3 5alpha-dihydrotestosterone + NADP+
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r
additional information Homo sapiens the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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isozymes 17beta-HSD3 and 17beta-HSD5
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Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland isozyme 17beta-HSD5 Homo sapiens
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gonad isozymes 17beta-HSD3 and 17beta-HSD5 Homo sapiens
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liver isozyme 17beta-HSD5 Homo sapiens
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prostate gland isozyme 17beta-HSD5 Homo sapiens
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testis high expression level of isozyme 17beta-HSD5 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-androstene-3,17-dione + NADPH + H+ isozymes 17beta-HSD3 and 17beta-HSD5 Homo sapiens testosterone + NADP+
-
r
5-androstenedione + NADPH isozyme 17beta-HSD3 Homo sapiens 5alpha-dihydrotestosterone + NADP+
-
r
additional information the isozyme 17beta-HSD3 is a critical determinant in steroid hormone biosynthesis Homo sapiens ?
-
?
additional information isozyme 17beta-HSD5 also shows 3alpha- and 20alpha-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase, and prostaglandin synthase activities Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
17beta-HSD3
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Homo sapiens
17beta-HSD5
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Homo sapiens