Cloned (Comment) | Organism |
---|---|
transient functional expression in COS-1 cells, stable functional expression in PC-3 cells and in LNCaP cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NADPH | strong inhibition of 3alpha-androstanediol oxidation | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.022 | - |
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide | pH 7.0, 37°C with NADP+ | Homo sapiens | |
0.026 | - |
5alpha-dihydrotestosterone | pH 7.0, 37°C, with NAD(P)H | Homo sapiens | |
0.042 | - |
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide | pH 7.0, 37°C with NAD+ | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NADH | Homo sapiens | reaction direction is regulated by the NAD+:NADPH relation in the cell | 3alpha-androstanediol + NAD+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
type 3 isozyme AKR1C2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide + NAD+ | - |
Homo sapiens | ? | - |
r | |
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide + NADP+ | - |
Homo sapiens | ? | - |
r | |
3alpha-androstanediol + NAD+ | oxidation utilizing NAD+ as a cofactor is the preferred reaction in vitro | Homo sapiens | 5alpha-dihydrotestosterone + NADH | - |
r | |
5alpha-dihydrotestosterone + NADH | reaction direction is regulated by the NAD+:NADPH relation in the cell | Homo sapiens | 3alpha-androstanediol + NAD+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
3alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
AKR1C2 | - |
Homo sapiens |
aldo-keto reductase 1C2 | - |
Homo sapiens |
More | enzyme belongs to the AKR1C subfamily of the AKR superfamily of enzymes | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0038 | - |
5alpha-dihydrotestosterone | pH 7.0, 37°C, with NAD(P)H | Homo sapiens | |
0.004 | - |
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide | pH 7.0, 37°C with NADP+ | Homo sapiens | |
0.0167 | - |
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide | pH 7.0, 37°C with NAD+ | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | oxidation utilizing NAD+ as a cofactor is the preferred reaction in vitro | Homo sapiens | |
NADH | - |
Homo sapiens | |
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |