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Literature summary for 1.1.1.49 extracted from

  • Allen, S.M.; Lim, E.E.; Jortzik, E.; Preuss, J.; Chua, H.H.; MacRae, J.I.; Rahlfs, S.; Haeussler, K.; Downton, M.T.; McConville, M.J.; Becker, K.; Ralph, S.A.
    Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target (2015), FEBS J., 282, 3808-3823 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ellagic acid mixed type inhibitor of glucose 6-phosphate activity Plasmodium falciparum
additional information presence of H2O2 only slightly alters enzyme activity or expression Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Plasmodium falciparum 5829
-

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q8IKU0 bifunctional glucose-6-phosphate 1-dehydrogenase/6-phosphogluconolactonase
-

Subunits

Subunits Comment Organism
? x * 109000, calculated from sequence, x * 100000, SDS-PAGE Plasmodium falciparum

Synonyms

Synonyms Comment Organism
PF14_0511
-
Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000076
-
pH 7.5, 25°C Plasmodium falciparum ellagic acid

Expression

Organism Comment Expression
Plasmodium falciparum no significant upregulation of expression in presence of artemisinin, chloroquine or methylene blue additional information

General Information

General Information Comment Organism
physiological function the enzyme is essential for the growth of blood stage parasites Plasmodium falciparum