Literature summary for 1.1.1.49 extracted from

Frederiks, W.M.; Bosch, K.S.; De Jong, J.S.; Van Noorden, C.J.
Post-translational regulation of glucose-6-phosphate dehydrogenase activity in (pre)neoplastic lesions in rat liver (2003), J. Histochem. Cytochem., 51, 105-112.

Search for more literature for 1.1.1.49

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.04	-	D-glucose 6-phosphate	22°C, liver extralesional parenchyma	Rattus norvegicus
0.2	-	D-glucose 6-phosphate	22°C, normal liver parenchyma	Rattus norvegicus
1.9	-	D-glucose 6-phosphate	22°C, liver (pre)neoplastic lesions	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-glucose 6-phosphate + NADP+	Rattus norvegicus	key regulatory enzyme of the pentose phosphate pathway, regulation mechanism study	D-glucono-1,5-lactone 6-phosphate + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelium	of vile ducts and blood vessel walls in portal tracts	Rattus norvegicus	-
hepatocellular carcinoma cell	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-
additional information	distribution pattern	Rattus norvegicus	-
parenchyma	extralesional and wild-type, the lesions show a 20fold higher, and extralesional parenchyma a 2fold higher, virtual flux at physiological substrate concentrations compared to normal parenchyma	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	quantification by in situ hydridization and immunohistochemistry	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glucose 6-phosphate + NADP+	-	Rattus norvegicus	D-glucono-1,5-lactone 6-phosphate + NADPH + H+	-	?
D-glucose 6-phosphate + NADP+	key regulatory enzyme of the pentose phosphate pathway, regulation mechanism study	Rattus norvegicus	D-glucono-1,5-lactone 6-phosphate + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
G6PD	-	Rattus norvegicus
glucose-6-phosphate dehydrogenase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
22	-	assay at room temperature	Rattus norvegicus

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Release 2023.1 (January 2023)