Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-phosphoadenosine 5'-diphosphoribose | - |
Cryptococcus neoformans | |
ADP | - |
Cryptococcus neoformans | |
AMP | only 2'-AMP | Cryptococcus neoformans | |
Cd2+ | - |
Cryptococcus neoformans | |
NADPH | - |
Cryptococcus neoformans | |
Zn2+ | - |
Cryptococcus neoformans |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0016 | - |
NADP+ | - |
Cryptococcus neoformans | |
0.024 | - |
D-glucose 6-phosphate | - |
Cryptococcus neoformans |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
? * 50000 SDS-PAGE | Cryptococcus neoformans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O + NADP+ | Cryptococcus neoformans | - |
D-gluconate 6-phosphate + NADPH + H+ | - |
? |
Organic Solvent | Comment | Organism |
---|---|---|
dimethylsulfoxide | substrate glucose and 40% DMSO (v/v): 10% remaining enzyme activity in HEPES buffer, 20% remaining enzyme activity in phosphate buffer | Cryptococcus neoformans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptococcus neoformans | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Cryptococcus neoformans |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
50 | - |
- |
Cryptococcus neoformans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose + NAD(P)+ | activity only with dimethylsulfoxide added by 40% (v/v) | Cryptococcus neoformans | D-gluconate + NAD(P)H | - |
? | |
D-glucose 6-phosphate + H2O + NADP+ | - |
Cryptococcus neoformans | D-gluconate 6-phosphate + NADPH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | ? * 50000 SDS-PAGE | Cryptococcus neoformans |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
- |
Cryptococcus neoformans |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8.5 | - |
Cryptococcus neoformans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | absolute specificity | Cryptococcus neoformans |