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Literature summary for 1.1.1.44 extracted from

  • Sarfraz, I.; Rasul, A.; Hussain, G.; Shah, M.A.; Zahoor, A.F.; Asrar, M.; Selamoglu, Z.; Ji, X.Y.; Adem, S.; Sarker, S.D.
    6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells From cancer initiation to metastasis and chemoresistance (2020), Biofactors, 46, 550-562 .
    View publication on PubMed
Search for more literature for 1.1.1.44

Inhibitors

Inhibitors Comment Organism Structure
1H-indol-1-yl(tiyophen-2-yl) methanon
-
 Homo sapiens
N-(4-chlorobenzoyl)-indole
-
 Homo sapiens
N-benzoylindole
-
 Homo sapiens
physcion 1,8-dihydroxy-3-methoxy-6-methyl-anthrachinon Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P52209
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information hyperactivation is mediated through post-transcriptional and post-translational modifications by YTH domain family 2 (YTHDF2), Nrf2 (nuclear factor erythroid 2-related factor 2), EGFR (epidermal growth factor receptor) and via direct structural interactions with ME1 (malic enzyme 1) Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Subunits

Subunits Comment Organism
homodimer monomers act independently to each other. Each monomer consists of large alpha-helical domain while small beta-alpha-beta domain, forming a six stranded beta-sheet Homo sapiens

Synonyms

Synonyms Comment Organism
6-phosphogluconate dehydrogenase
-
 Homo sapiens
6PGD
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens overexpressed in number of cancer types. Upregulated expression of the enzyme (6PGD) provides metabolic as well as defensive advantage to cancer cells, thus, promoting their proliferative and metastatic potential. Enhanced 6PGD expression also performs key role in development of chemoresistance as well as radiation resistance in cancer up

General Information

General Information Comment Organism
drug target the enzyme might serve as promising therapeutic target for the treatment of cancers in which the enzyme (6PGD) is aberrantly overexpressed Homo sapiens