Literature summary for 1.1.1.44 extracted from

Adem, S.; Ciftci, M.
Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study (2007), J. Enzyme Inhib. Med. Chem., 22, 751-754.

Search for more literature for 1.1.1.44

Inhibitors

Inhibitors	Comment	Organism	Structure
amoxicillin	competitive	Homo sapiens
clindamycin	competitive	Homo sapiens
Imipenem	noncompetitive	Homo sapiens
lornoxicam	noncompetitive	Homo sapiens
metronidazole	noncompetitive	Homo sapiens
ornidazole	noncompetitive	Homo sapiens
Vancomycin	competitive	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
25.75	-	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-phospho-D-gluconate + NADP+	-	Homo sapiens	D-ribulose 5-phosphate + CO2 + NADPH + H+	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.4	-	lornoxicam	25°C, pH 8.0	Homo sapiens
0.57	-	metronidazole	25°C, pH 8.0	Homo sapiens
0.77	-	Imipenem	25°C, pH 8.0	Homo sapiens
42.4	-	ornidazole	25°C, pH 8.0	Homo sapiens
65.6	-	Vancomycin	25°C, pH 8.0	Homo sapiens
130.2	-	clindamycin	25°C, pH 8.0	Homo sapiens
287.6	-	amoxicillin	25°C, pH 8.0	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.17	-	25°C, pH 8.0	Homo sapiens	lornoxicam
0.23	-	25°C, pH 8.0	Homo sapiens	metronidazole
0.43	-	25°C, pH 8.0	Homo sapiens	Imipenem
21.79	-	25°C, pH 8.0	Homo sapiens	ornidazole
46.39	-	25°C, pH 8.0	Homo sapiens	Vancomycin
117.4	-	25°C, pH 8.0	Homo sapiens	clindamycin
287.4	-	25°C, pH 8.0	Homo sapiens	amoxicillin

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Release 2023.1 (January 2023)