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Literature summary for 1.1.1.44 extracted from

  • Toews, M.L.; Kanji, M.I.; Carper, R.W.
    6-Phosphogluconate dehydrogenase. Purification and kinetics (1976), J. Biol. Chem., 251, 7127-7131.
    View publication on PubMed
Search for more literature for 1.1.1.44

General Stability

General Stability Organism
enzyme loses no activity on dialysis overnight against 10 mM EDTA Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
CO2
-
 Sus scrofa
Mg2+ acts as an inhibitor above 20 mM Sus scrofa
NADPH
-
 Homo sapiens
NADPH
-
 Rattus norvegicus
NADPH
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0135
-
 6-phosphogluconate
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Cyberlindnera jadinii 5737
-
cytoplasm
-
 Homo sapiens 5737
-
cytoplasm
-
 Rattus norvegicus 5737
-
cytoplasm
-
 Sus scrofa 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Cyberlindnera jadinii
Mg2+
-
 Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
83000
-
 gel filtration, method of Ornstein and Davis Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-phospho-D-gluconate + NADP+ Cyberlindnera jadinii
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ Rattus norvegicus
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ Sus scrofa
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+ Ovis aries
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Cyberlindnera jadinii
-
-
-
Homo sapiens
-
 human
-
Ovis aries
-
 sheep
-
Rattus norvegicus
-
 rat
-
Sus scrofa
-
 pig
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Rattus norvegicus
-
 Sus scrofa
-
 Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-
erythrocyte
-
 Ovis aries
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Sus scrofa
-
liver
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.41
-
-
 Sus scrofa
1.89
-
 supernatant fraction Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-phospho-D-gluconate + NADP+
-
 Cyberlindnera jadinii D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+
-
 Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+
-
 Sus scrofa D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r
6-phospho-D-gluconate + NADP+
-
 Ovis aries D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
7.5 10
-
 Sus scrofa