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Literature summary for 1.1.1.433 extracted from

  • Peck, S.C.; Denger, K.; Burrichter, A.; Irwin, S.M.; Balskus, E.P.; Schleheck, D.
    A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia (2019), Proc. Natl. Acad. Sci. USA, 116, 3171-3176 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.433

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-sulfoacetaldehyde + NADH + H+ Bilophila wadsworthia
-
 isethionate + NAD+
-
 ?
2-sulfoacetaldehyde + NADH + H+ Bilophila wadsworthia 3_1_6
-
 isethionate + NAD+
-
 ?
additional information Bilophila wadsworthia no substrate: acetaldehyde ?
-
-
additional information Bilophila wadsworthia 3_1_6 no substrate: acetaldehyde ?
-
-

Organism

Organism UniProt Comment Textmining
Bilophila wadsworthia E5Y946
-
-
Bilophila wadsworthia 3_1_6 E5Y946
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-sulfoacetaldehyde + NADH + H+
-
 Bilophila wadsworthia isethionate + NAD+
-
 ?
2-sulfoacetaldehyde + NADH + H+
-
 Bilophila wadsworthia 3_1_6 isethionate + NAD+
-
 ?
additional information no substrate: acetaldehyde Bilophila wadsworthia ?
-
-
additional information no substrate: acetaldehyde Bilophila wadsworthia 3_1_6 ?
-
-

Synonyms

Synonyms Comment Organism
HMPREF0179_02714
-
 Bilophila wadsworthia
sarD
-
 Bilophila wadsworthia
tauF
-
 Bilophila wadsworthia

General Information

General Information Comment Organism
physiological function in the taurine desulfonation pathway, an initial deamination of taurine to sulfoacetaldehyde by a taurine:pyruvate aminotransferase is followed by reduction of sulfoacetaldehyde to isethionate (2-hydroxyethanesulfonate) by NADH-dependent reductase SarD. Isethionate is then cleaved to sulfite and acetaldehyde by glycyl radical enzyme isethionate sulfite-lyase IslA Bilophila wadsworthia