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Literature summary for 1.1.1.428 extracted from

  • Korwar, S.; Morris, B.; Parikh, H.; Coover, R.; Doughty, T.; Love, I.; Hilbert, B.; Royer, W.J.; Kellogg, G.; Grossman, S.; Ellis, K.
    Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal binding protein (CtBP) (2016), Bioorg. Med. Chem., 24, 2707-2715 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.428

Inhibitors

Inhibitors Comment Organism Structure
(2Z)-2-(hydroxyimino)-3-phenylpropanoic acid potent inhibitor Homo sapiens
(2Z)-2-hydrazinylidene-3-phenylpropanoic acid
-
 Homo sapiens
1-phenylpropan-2-one
-
 Homo sapiens
2-(hydroxyimino)-3-(2-methoxyphenyl)propanoic acid
-
 Homo sapiens
2-(hydroxyimino)-3-(3-hydroxyphenyl)propanoic acid
-
 Homo sapiens
2-(hydroxyimino)-3-(3-methoxyphenyl)propanoic acid
-
 Homo sapiens
2-(hydroxyimino)-3-(4-hydroxyphenyl)propanoic acid
-
 Homo sapiens
2-(hydroxyimino)-3-(4-methoxyphenyl)propanoic acid
-
 Homo sapiens
2-(hydroxyimino)-3-m-tolylpropanoic acid
-
 Homo sapiens
2-(hydroxyimino)-3-o-tolylpropanoic acid
-
 Homo sapiens
2-(hydroxyimino)-3-p-tolylpropanoic acid
-
 Homo sapiens
2-(hydroxyimino)-3-phenylpropanoic acid potent inhibitor Homo sapiens
2-benzylprop-2-enoic acid
-
 Homo sapiens
2-hydrazono-3-phenylpropanoic acid
-
 Homo sapiens
2-Oxopropanoic acid
-
 Homo sapiens
3-(2-chlorophenyl)-2-(hydroxyimino)propanoic acid
-
 Homo sapiens
3-(3-chlorophenyl)-2-(hydroxyimino)propanoic acid
-
 Homo sapiens
3-(4-chlorophenyl)-2-(hydroxyimino)propanoic acid
-
 Homo sapiens
3-(4-cyanophenyl)-2-(hydroxyimino)propanoic acid
-
 Homo sapiens
3-(4-fluorophenyl)-2-(hydroxyimino)propanoic acid
-
 Homo sapiens
3-phenyl-2-thioxopropanoic acid
-
 Homo sapiens
3-Phenylpropanoic acid
-
 Homo sapiens
4-(methylsulfanyl)-2-oxobutanoate substrate inhibition Homo sapiens
benzylpropanedioic acid
-
 Homo sapiens
oxo(phenyl)acetic acid
-
 Homo sapiens
oxo(phenylamino)acetic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-(methylsulfanyl)-2-oxobutanoate + NADH + H+ Homo sapiens
-
 (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-(methylsulfanyl)-2-oxobutanoate + NADH + H+
-
 Homo sapiens (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
C-terminal-binding protein 1
-
 Homo sapiens
CtBP
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00017
-
 at pH 7.1 and 25°C Homo sapiens 3-(3-chlorophenyl)-2-(hydroxyimino)propanoic acid
0.00018
-
 at pH 7.1 and 25°C Homo sapiens 3-(4-chlorophenyl)-2-(hydroxyimino)propanoic acid
0.00024
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-phenylpropanoic acid
0.0003
-
 at pH 7.1 and 25°C Homo sapiens 3-(4-fluorophenyl)-2-(hydroxyimino)propanoic acid
0.00032
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-p-tolylpropanoic acid
0.00048
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-m-tolylpropanoic acid
0.00072
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-(3-hydroxyphenyl)propanoic acid
0.00088
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-(3-methoxyphenyl)propanoic acid
0.0009
-
 at pH 7.1 and 25°C Homo sapiens 3-(4-cyanophenyl)-2-(hydroxyimino)propanoic acid
0.00216
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-(4-methoxyphenyl)propanoic acid
0.0024
-
 at pH 7.1 and 25°C Homo sapiens (2Z)-2-(hydroxyimino)-3-phenylpropanoic acid
0.00734
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-(4-hydroxyphenyl)propanoic acid
0.00765
-
 at pH 7.1 and 25°C Homo sapiens 3-(2-chlorophenyl)-2-(hydroxyimino)propanoic acid
0.00873
-
 at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-o-tolylpropanoic acid
0.1
-
 IC50 above 0.1 mM, at pH 7.1 and 25°C Homo sapiens 2-(hydroxyimino)-3-(2-methoxyphenyl)propanoic acid
300
-
 at pH 7.1 and 25°C Homo sapiens 4-(methylsulfanyl)-2-oxobutanoate