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Literature summary for 1.1.1.428 extracted from
- 2-Keto-4-methylthiobutyrate, an intermediate in the methionine salvage pathway, is a good substrate for CtBP1 (2007), Biochem. Biophys. Res. Commun., 352, 903-906 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxocaproate + NADH + H+ | 1040% activity compared to pyruvate | Homo sapiens | ? | - |
? |  |
| 2-oxogluconate + NADH + H+ | 20% activity compared to pyruvate | Homo sapiens | ? | - |
? | |
| 2-oxoglutarate + NADH + H+ | 80% activity compared to pyruvate | Homo sapiens | ? | - |
? | |
| 2-oxoisocaproate + NADH + H+ | 430% activity compared to pyruvate | Homo sapiens | ? | - |
? | |
| 2-oxovalerate + NADH + H+ | 160% activity compared to pyruvate | Homo sapiens | ? | - |
? | |
| 3-phosphohydroxypyruvate + NADH + H+ | 10% activity compared to pyruvate | Homo sapiens | ? | - |
? | |
| 4-(methylsulfanyl)-2-oxobutanoate + NADH + H+ | best substrate, 8120% activity compared to pyruvate | Homo sapiens | (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD+ | - |
? | |
| glyoxylate + NADH + H+ | 350% activity compared to pyruvate | Homo sapiens | ? | - |
? | |
| oxaloacetate + NADH + H+ | 30% activity compared to pyruvate | Homo sapiens | ? | - |
? | |
| phenylpyruvate + NADH + H+ | 420% activity compared to pyruvate | Homo sapiens | ? | - |
? | |
| pyruvate + NADH + H+ | 100% activity | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| C-terminal-binding protein 1 | - |
Homo sapiens |
| CTBP1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Homo sapiens | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0084 | - |
3-phosphohydroxypyruvate | at pH 7.1 and 30°C | Homo sapiens | |
| 0.012 | - |
2-oxogluconate | at pH 7.1 and 30°C | Homo sapiens | |
| 0.019 | - |
oxaloacetate | at pH 7.1 and 30°C | Homo sapiens | |
| 0.049 | - |
2-oxoglutarate | at pH 7.1 and 30°C | Homo sapiens | |
| 0.065 | - |
pyruvate | at pH 7.1 and 30°C | Homo sapiens | |
| 0.103 | - |
2-oxovalerate | at pH 7.1 and 30°C | Homo sapiens | |
| 0.228 | - |
2-oxoisocaproate | at pH 7.1 and 30°C | Homo sapiens | |
| 0.273 | - |
phenylpyruvate | at pH 7.1 and 30°C | Homo sapiens | |
| 0.28 | - |
glyoxylate | at pH 7.1 and 30°C | Homo sapiens | |
| 0.677 | - |
2-oxocaproate | at pH 7.1 and 30°C | Homo sapiens | |
| 5.28 | - |
4-(methylsulfanyl)-2-oxobutanoate | at pH 7.1 and 30°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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