Literature summary for 1.1.1.42 extracted from

Munoz-Vargas, M.A.; Gonzalez-Gordo, S.; Canas, A.; Lopez-Jaramillo, J.; Palma, J.M.; Corpas, F.J.
Endogenous hydrogen sulfide (H2S) is up-regulated during sweet pepper (Capsicum annuum L.) fruit ripening. In vitro analysis shows that NADP-dependent isocitrate dehydrogenase (ICDH) activity is inhibited by H2S and NO (2018), Nitric Oxide, 81, 36-45 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
DEA-NONOate	48% reduction of activity at 5 mM	Capsicum annuum
hydrogen sulfide	-	Capsicum annuum
additional information	not affected by glutathione	Capsicum annuum
Na2S	around 23% inhibition with 1 to 5 mM Na2S	Capsicum annuum
NaHS	2 and 10 mM NaHS used as H2S donors result in a decrease in enzyme activity of up to 36% and 45%, respectively	Capsicum annuum
nitric oxide	-	Capsicum annuum
peroxynitrite	causes a 26% inhibition in enzyme activity with 5 mM SIN-1	Capsicum annuum
S-nitrosocysteine	96% reduction of activity at 5 mM	Capsicum annuum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
isocitrate + NADP+	Capsicum annuum	-	2-oxoglutarate + CO2 + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Capsicum annuum	A0A2G2Y555	cultvar Melchor	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
nitration	the enzyme protein is a target of inhibitory nitric oxide-mediated posttranslational modification (nitration)	Capsicum annuum
S-nitrosylation	the enzyme protein is a target of inhibitory H2S-mediated posttranslational modification (S-nitrosylation)	Capsicum annuum

Purification (Commentary)

Purification (Comment)	Organism
ammonium sulfate precipitation	Capsicum annuum

Source Tissue

Source Tissue	Comment	Organism	Textmining
fruit	-	Capsicum annuum	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
isocitrate + NADP+	-	Capsicum annuum	2-oxoglutarate + CO2 + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
ICDH	-	Capsicum annuum
NADP-dependent isocitrate dehydrogenase	-	Capsicum annuum
NADP-ICDH	-	Capsicum annuum
NADP-isocitrate dehydrogenase	-	Capsicum annuum

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Capsicum annuum

Expression

Organism	Comment	Expression
Capsicum annuum	enzyme expression increases 1.7fold during pepper fruit ripening	up

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Release 2023.1 (January 2023)