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Literature summary for 1.1.1.42 extracted from

  • Leterrier, M.; Barroso, J.; Palma, J.; Corpas, F.
    Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots (2012), Biol. Plant., 56, 705-710.
No PubMed abstract available
Search for more literature for 1.1.1.42

Cloned(Commentary)

Cloned (Comment) Organism
gene At1g65930 Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
3-morpholinosydnonimine 44% inhibition at 5 mM of leaf and root enzymes Arabidopsis thaliana
GSH inhibits the leaf enzyme by 40% at 5 mM, but not the root enzyme Arabidopsis thaliana
H2O2 affects the root enzyme slightly but not the enzyme from leaves Arabidopsis thaliana
peroxynitrite
-
 Arabidopsis thaliana
S-nitrosoglutathione 70.5% inhibition at 5 mM of the leaf enzyme, 37.3% of the root enzyme Arabidopsis thaliana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0044
-
 NADP+ pH 7.6, 25°C, leaf enzyme Arabidopsis thaliana
0.042
-
 D-isocitrate pH 7.6, 25°C, leaf enzyme Arabidopsis thaliana
0.0616
-
 NADP+ pH 7.6, 25°C, root enzyme Arabidopsis thaliana
0.239
-
 D-isocitrate pH 7.6, 25°C, root enzyme Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Arabidopsis thaliana 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-isocitrate + NADP+ Arabidopsis thaliana
-
 2-oxoglutarate + CO2 + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9SRZ6 gene At1g65930
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Arabidopsis thaliana
-
root
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-isocitrate + NADP+
-
 Arabidopsis thaliana 2-oxoglutarate + CO2 + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
NADP-dependent isocitrate dehydrogenase
-
 Arabidopsis thaliana
NADP-ICDH
-
 Arabidopsis thaliana
NADP-isocitrate dehydrogenase
-
 Arabidopsis thaliana

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45
-
 root enzyme Arabidopsis thaliana
60
-
 leaf enzyme Arabidopsis thaliana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Arabidopsis thaliana