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Literature summary for 1.1.1.42 extracted from

  • Labussiere, M.; Idbaih, A.; Wang, X.W.; Marie, Y.; Boisselier, B.; Falet, C.; Paris, S.; Laffaire, J.; Carpentier, C.; Criniere, E.; Ducray, F.; El Hallani, S.; Mokhtari, K.; Hoang-Xuan, K.; Delattre, J.Y.; Sanson, M.
    All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2 (2010), Neurology, 74, 1886-1890.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information analysis of IDH1 mutations in chromosome 19, 1p19q, and prognostic impact in glioma patients, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol IDH1 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NADP+ Homo sapiens
-
2-oxoglutarate + NADPH + H+ + CO2
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NADP+
-
Homo sapiens 2-oxoglutarate + NADPH + H+ + CO2
-
r

Synonyms

Synonyms Comment Organism
cytosolic NADPH-dependent isocitrate dehydrogenase
-
Homo sapiens
IDH1
-
Homo sapiens
NADPH-dependent isocitrate dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
additional information all tumors with complete 1p19q codeletion are mutated in the IDH1 or IDH2 gene. Glioma patients having IDH1/IDH2 mutations show inproved median overall survival, different outcomes in WHO grade II and III gliomas according to the 1p19q and IDH1/IDH2 statusses, overview Homo sapiens