Literature summary for 1.1.1.42 extracted from

Yang, E.S.; Lee, J.H.; Park, J.W.
Ethanol induces peroxynitrite-mediated toxicity through inactivation of NADP(+)-dependent isocitrate dehydrogenase and superoxide dismutase (2008), Biochimie, 90, 1316-1324.

Search for more literature for 1.1.1.42

Inhibitors

Inhibitors	Comment	Organism	Structure
peroxynitrite	ethanol toxicity is mediated by peroxynitrite and the peroxynitrite-mediated damage to NADP+-dependent isocitrate dehydrogenase and superoxide dismutase may be resulting in the perturbation of the cellular antioxidant defense systems and subsequently lead to a pro-oxidant condition	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ICDH	-	Homo sapiens
NADP+-dependent isocitrate dehydrogenase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)