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Literature summary for 1.1.1.42 extracted from

  • Kil, I.S.; Huh, T.L.; Lee, Y.S.; Lee, Y.M.; Park, J.W.
    Regulation of replicative senescence by NADP+ -dependent isocitrate dehydrogenase (2006), Free Radic. Biol. Med., 40, 110-119.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
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mitochondrion
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Mus musculus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme plays an important regulatory role in cellular defense against oxidative stress and in senescence ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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both mitochondrial and cytosolic isoform, expression in human fibroblast. Inverse relationship between the amount of enzyme expressed in target cells and their susceptibility to senescence as shown by changes in replicative potential, cell cycle, expression of p21 and p53. Lipid peroxidation, oxidative DNA damage, and intracellular peroxide generation is higher and cellular redox status shifts to a prooxidant condition in cells expressing low levels of enzyme
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme plays an important regulatory role in cellular defense against oxidative stress and in senescence Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
IDPm
-
Mus musculus