Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | enzyme plays an important regulatory role in cellular defense against oxidative stress and in senescence | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
both mitochondrial and cytosolic isoform, expression in human fibroblast. Inverse relationship between the amount of enzyme expressed in target cells and their susceptibility to senescence as shown by changes in replicative potential, cell cycle, expression of p21 and p53. Lipid peroxidation, oxidative DNA damage, and intracellular peroxide generation is higher and cellular redox status shifts to a prooxidant condition in cells expressing low levels of enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme plays an important regulatory role in cellular defense against oxidative stress and in senescence | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDPm | - |
Mus musculus |