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Literature summary for 1.1.1.42 extracted from
- Isolation and characterization of NADP+-specific isocitrate dehydrogenase from the pupa of Bombyx mori (1977), J. Biochem., 82, 449-454.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-oxoglutarate | substrate inhibition | Bombyx mori |  |
| adenosine-3',5'-cyclic monophosphate | - |
Bombyx mori | |
| Ag+ | decarboxylation of isocitrate and oxalosuccinate | Bombyx mori | |
| citrate | - |
Bombyx mori | |
| Maleate | - |
Bombyx mori | |
| monoiodoacetate | - |
Bombyx mori | |
| oxaloacetate | - |
Bombyx mori | |
| p-chloromercuribenzoate | - |
Bombyx mori | |
| Zn2+ | - |
Bombyx mori | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | absolute requirement for divalent cations | Bombyx mori | |
| Mg2+ | absolute requirement for divalent cations | Bombyx mori | |
| Mn2+ | absolute requirement for divalent cations | Bombyx mori | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 86000 | - |
gel filtration | Bombyx mori |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isocitrate + NADP+ | Bombyx mori | - |
2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bombyx mori | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bombyx mori |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pupa | - |
Bombyx mori | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 6 months, 10% loss of activity | Bombyx mori |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isocitrate + NADP+ | - |
Bombyx mori | 2-oxoglutarate + NADPH + H+ + CO2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 23 | - |
- |
Bombyx mori |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
- |
Bombyx mori |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | - |
2-oxoglutarate + CO2 + NADPH | Bombyx mori |
| 7.8 | - |
isocitrate + NADP+ | Bombyx mori |
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