Literature summary for 1.1.1.417 extracted from

Lee, A.; Banta, A.; Wei, J.; Kiemle, D.; Feng, J.; Giner, J.; Welander, P.
C-4 sterol demethylation enzymes distinguish bacterial and eukaryotic sterol synthesis (2018), Proc. Natl. Acad. Sci. USA, 115, 5884-5889 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4-desmethyllanosterol + NAD(P)+	Methylococcus capsulatus	-	4-desmethyllanosterone + NAD(P)H + CO2 + H+	-	?
4-desmethyllanosterol + NAD(P)+	Methylococcus capsulatus Texas H156DRAFT2756-2755	-	4-desmethyllanosterone + NAD(P)H + CO2 + H+	-	?
lanosterol + NAD(P)+	Methylococcus capsulatus	-	lanosterone + NAD(P)H + CO2 + H+	-	?
lanosterol + NAD(P)+	Methylococcus capsulatus Texas H156DRAFT2756-2755	-	lanosterone + NAD(P)H + CO2 + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Methylococcus capsulatus	-	-	-
Methylococcus capsulatus Texas H156DRAFT2756-2755	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-desmethyllanosterol + NAD(P)+	-	Methylococcus capsulatus	4-desmethyllanosterone + NAD(P)H + CO2 + H+	-	?
4-desmethyllanosterol + NAD(P)+	-	Methylococcus capsulatus Texas H156DRAFT2756-2755	4-desmethyllanosterone + NAD(P)H + CO2 + H+	-	?
lanosterol + NAD(P)+	-	Methylococcus capsulatus	lanosterone + NAD(P)H + CO2 + H+	-	?
lanosterol + NAD(P)+	-	Methylococcus capsulatus Texas H156DRAFT2756-2755	lanosterone + NAD(P)H + CO2 + H+	-	?

Synonyms

Synonyms	Comment	Organism
sdmB	-	Methylococcus capsulatus

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Methylococcus capsulatus
NADPH	-	Methylococcus capsulatus

General Information

General Information	Comment	Organism
metabolism	the enzyme participates in sterol C-4 demethylation	Methylococcus capsulatus

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Release 2023.1 (January 2023)