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Literature summary for 1.1.1.41 extracted from

  • Kang, M.R.; Kim, M.S.; Oh, J.E.; Kim, Y.R.; Song, S.Y.; Seo, S.I.; Lee, J.Y.; Yoo, N.J.; Lee, S.H.
    Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers (2009), Int. J. Cancer, 125, 353-355.
    View publication on PubMed
Search for more literature for 1.1.1.41

Cloned(Commentary)

Cloned (Comment) Organism
genotyping in diverse cancer cell lines, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutational analysis of IDH1 codon 132 in 1185 cancer samples, overview Homo sapiens
R132C naturally occuring IDH1 mutation Homo sapiens
R132G naturally occuring IDH1 mutation Homo sapiens
R132H naturally occuring IDH1 mutation Homo sapiens
R132L naturally occuring IDH1 mutation Homo sapiens
R132S naturally occuring IDH1 mutation Homo sapiens
R132V naturally occuring IDH1 mutation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate + NAD+ Homo sapiens IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates 2-oxoglutarate + NADH + H+ + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell acute lymphoblastic leukemia cell
-
 Homo sapiens
-
breast carcinoma cell
-
 Homo sapiens
-
colonic carcinoma cell
-
 Homo sapiens
-
esophageal cancer cell
-
 Homo sapiens
-
glioblastoma cell
-
 Homo sapiens
-
glioma cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
kidney carcinoma cell
-
 Homo sapiens
-
leukemia cell acute Homo sapiens
-
lung carcinoma cell
-
 Homo sapiens
-
meningioma cell malignant Homo sapiens
-
mesothelioma cell
-
 Homo sapiens
-
myeloma cell multiple Homo sapiens
-
ovary carcinoma cell
-
 Homo sapiens
-
prostate adenocarcinoma cell
-
 Homo sapiens
-
prostate carcinoma cell
-
 Homo sapiens
-
skin carcinoma cell
-
 Homo sapiens
-
stomach carcinoma cell
-
 Homo sapiens
-
urinary bladder carcinoma cell
-
 Homo sapiens
-
uterine cervix carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate + NAD+
-
 Homo sapiens 2-oxoglutarate + NADH + H+ + CO2
-
 ?
isocitrate + NAD+ IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates Homo sapiens 2-oxoglutarate + NADH + H+ + CO2
-
 ?

Synonyms

Synonyms Comment Organism
IDH1
-
 Homo sapiens