Activating Compound | Comment | Organism | Structure |
---|---|---|---|
fumarate | fumarate activates at high concentrations | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | isoform ME2 is a potential anticancer target | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
embonic acid | - |
Homo sapiens | |
NPD389 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NADP+ | Homo sapiens | - |
pyruvate + CO2 + NADPH + H+ | - |
r | |
pyruvate + CO2 + NADPH + H+ | Homo sapiens | - |
(S)-malate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
bone cancer cell | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
colorectal cancer cell | - |
Homo sapiens | - |
erythroleukemia cell | - |
Homo sapiens | - |
GBM-8401 cell | - |
Homo sapiens | - |
glioma cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
leukemia cell | - |
Homo sapiens | - |
LN-229 cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
melanoma cell | - |
Homo sapiens | - |
osteosarcoma cell | - |
Homo sapiens | - |
pancreatic cancer cell | - |
Homo sapiens | - |
skin cancer cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-malate + NADP+ | - |
Homo sapiens | pyruvate + CO2 + NADPH + H+ | - |
r | |
pyruvate + CO2 + NADPH + H+ | - |
Homo sapiens | (S)-malate + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
m-NAD(P)-ME | - |
Homo sapiens |
ME2 | - |
Homo sapiens |
NADP(+)-dependent mitochondrial malic enzyme 2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0014 | - |
pH and temperature not specified in the publication | Homo sapiens | embonic acid |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | isoform ME2 expression increases as tumor progression and invasion capabilities of cells are increased | up |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme overexpression in cancer cells leads to decreased cellular differentiation, enhanced invasiveness associated with cellular differentiation proteins, modulation of AKT and AMPK signalling, modulation of p53 levels and its downstream target p21, increased cellular growth rate and proliferation with decreasing apoptotic rate, as well as modulation of glutamine oxidation via the Krebs cycle | Homo sapiens |