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Literature summary for 1.1.1.40 extracted from

  • Sarfraz, I.; Rasul, A.; Hussain, G.; Hussain, S.M.; Ahmad, M.; Nageen, B.; Jabeen, F.; Selamoglu, Z.; Ali, M.
    Malic enzyme 2 as a potential therapeutic drug target for cancer (2018), IUBMB Life, 70, 1076-1083 .
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
fumarate fumarate activates at high concentrations Homo sapiens

Application

Application Comment Organism
medicine isoform ME2 is a potential anticancer target Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
embonic acid
-
Homo sapiens
NPD389
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NADP+ Homo sapiens
-
pyruvate + CO2 + NADPH + H+
-
r
pyruvate + CO2 + NADPH + H+ Homo sapiens
-
(S)-malate + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
bone cancer cell
-
Homo sapiens
-
breast cancer cell
-
Homo sapiens
-
colorectal cancer cell
-
Homo sapiens
-
erythroleukemia cell
-
Homo sapiens
-
GBM-8401 cell
-
Homo sapiens
-
glioma cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
hepatoma cell
-
Homo sapiens
-
K-562 cell
-
Homo sapiens
-
leukemia cell
-
Homo sapiens
-
LN-229 cell
-
Homo sapiens
-
lung cancer cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
melanoma cell
-
Homo sapiens
-
osteosarcoma cell
-
Homo sapiens
-
pancreatic cancer cell
-
Homo sapiens
-
skin cancer cell
-
Homo sapiens
-
U2-OS cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NADP+
-
Homo sapiens pyruvate + CO2 + NADPH + H+
-
r
pyruvate + CO2 + NADPH + H+
-
Homo sapiens (S)-malate + NADP+
-
r

Synonyms

Synonyms Comment Organism
m-NAD(P)-ME
-
Homo sapiens
ME2
-
Homo sapiens
NADP(+)-dependent mitochondrial malic enzyme 2
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0014
-
pH and temperature not specified in the publication Homo sapiens embonic acid

Expression

Organism Comment Expression
Homo sapiens isoform ME2 expression increases as tumor progression and invasion capabilities of cells are increased up

General Information

General Information Comment Organism
physiological function enzyme overexpression in cancer cells leads to decreased cellular differentiation, enhanced invasiveness associated with cellular differentiation proteins, modulation of AKT and AMPK signalling, modulation of p53 levels and its downstream target p21, increased cellular growth rate and proliferation with decreasing apoptotic rate, as well as modulation of glutamine oxidation via the Krebs cycle Homo sapiens